{"id":"W2203819430","doi":"10.1038/cddis.2015.381","title":"Obesity and cancer, a case for insulin signaling","year":2015,"lang":"en","type":"review","venue":"Cell Death and Disease","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Overweight; Hyperinsulinemia; Obesity; Insulin resistance; Medicine; Cancer; Body mass index; Type 2 diabetes; Disease; Fatty liver; Diabetes mellitus; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006331466,0.0006026918,0.001011087,0.001483513,0.0004820964,0.001561726,0.000798647,0.001945138,0.003834858],"category_scores_gemma":[0.0009270073,0.0002211647,0.0005576539,0.001703957,0.001080081,0.002333086,0.001118687,0.003770554,0.00228696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001071869,"about_ca_system_score_gemma":0.001300827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001001314,"about_ca_topic_score_gemma":0.001735,"domain_scores_codex":[0.9997191,0.00005557729,0.00002967097,0.00004515869,0.0001108963,0.00003947976],"domain_scores_gemma":[0.9996622,0.0001401353,0.00002822676,0.0000168094,0.0001050415,0.0000477031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001118202,0.00005991764,0.0003856499,0.00884702,0.0000927191,0.0006229682,0.0002038576,0.0002921806,0.002136791,0.02402057,0.1548537,0.8083728],"study_design_scores_gemma":[0.00000611096,0.00002756011,0.0002824056,0.001193318,0.00002203161,0.00103928,0.00007274687,0.00002626273,0.0001490859,0.004362314,0.9928085,0.00001041788],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009098333,0.9952611,0.0001388476,0.002218959,0.001057152,0.000001971718,0.0000115387,0.00001005409,0.001209409],"genre_scores_gemma":[0.0008094871,0.9952434,0.0001884085,0.001714818,0.0007903421,0.000004331839,0.00002285776,0.000002808218,0.001223505],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003834858,"threshold_uncertainty_score":0.01282883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03950355456338837,"score_gpt":0.3178349690359031,"score_spread":0.2783314144725147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}