{"id":"W2204286903","doi":"10.1007/978-94-007-2888-2_29","title":"The Role of C2 Domains in PKC Signaling","year":2012,"lang":"en","type":"review","venue":"Advances in experimental medicine and biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"C2 domain; Protein kinase C; Cell biology; HAMP domain; Signal transduction; Protein kinase domain; Kinase; Phosphorylation; Proto-oncogene tyrosine-protein kinase Src; Biology; Binding domain; Chemistry; Binding site; Biochemistry; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006948002,0.001233901,0.001161008,0.001372021,0.0003535612,0.0013156,0.001217348,0.001420163,0.002162089],"category_scores_gemma":[0.0006104663,0.0003723738,0.000369523,0.001800283,0.001024181,0.001623503,0.0009778771,0.002255443,0.001710249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001173276,"about_ca_system_score_gemma":0.001332679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001287269,"about_ca_topic_score_gemma":0.001554716,"domain_scores_codex":[0.9998198,0.00001737761,0.00002238994,0.00004421391,0.00006354779,0.00003265213],"domain_scores_gemma":[0.9997543,0.0001057642,0.00004185503,0.00001306934,0.00005469565,0.00003041161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002264431,0.00006559854,0.0001828586,0.007880443,0.00006720176,0.0003003273,0.00003599841,0.0006444712,0.008136445,0.007721727,0.01902916,0.9557093],"study_design_scores_gemma":[0.0000389094,0.00006251202,0.0008990986,0.001267859,0.00009090034,0.001005356,0.00004041996,0.0001937826,0.003191957,0.003890198,0.9892883,0.00003057881],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002116518,0.9980263,0.0002881233,0.0002646909,0.000223179,0.000004066573,0.00001807198,0.000007025497,0.000956854],"genre_scores_gemma":[0.001328003,0.9971295,0.0002864005,0.000223794,0.0002578822,0.000006678024,0.00004425756,0.000001750908,0.0007218625],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002162089,"threshold_uncertainty_score":0.008512735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02933964441098832,"score_gpt":0.3677522965922025,"score_spread":0.3384126521812142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}