{"id":"W2204286903","doi":"10.1007/978-94-007-2888-2_29","title":"The Role of C2 Domains in PKC Signaling","year":2012,"lang":"en","type":"review","venue":"Advances in experimental medicine and biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"C2 domain; Protein kinase C; Cell biology; HAMP domain; Signal transduction; Protein kinase domain; Kinase; Phosphorylation; Proto-oncogene tyrosine-protein kinase Src; Biology; Binding domain; Chemistry; Binding site; Biochemistry; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003148503,0.0002038603,0.0005644288,0.00008781441,0.00003990443,0.000002097468,0.0001437402,0.0002116483,0.0000108926],"category_scores_gemma":[0.00004194563,0.0001209867,0.00006706049,0.0001130435,0.0003818485,0.0000047841,0.0001011376,0.0001274954,6.703729e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001883261,"about_ca_system_score_gemma":0.00003111478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002012634,"about_ca_topic_score_gemma":0.00002532757,"domain_scores_codex":[0.9988234,0.0001690415,0.0004711047,0.0002539011,0.00004958046,0.0002329638],"domain_scores_gemma":[0.9994885,0.00007914529,0.0002089912,0.0001677149,0.00001183018,0.00004378341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003355238,0.00004456612,0.0002044061,0.000328755,0.00002084687,0.000001416688,0.00008665102,7.894904e-7,0.04806708,0.001775165,0.000002109693,0.9494346],"study_design_scores_gemma":[0.0003414925,0.0002468807,0.000002112024,0.001122665,0.0000229303,0.00001685302,0.0004594815,0.000001579956,0.01493536,0.0003262407,0.9823867,0.0001377116],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001478192,0.9974817,0.00001657179,0.00001153601,0.0001379542,0.0003016,0.000004423678,0.000002435575,0.0005656016],"genre_scores_gemma":[0.06619226,0.9332252,0.0001027346,0.00002859166,0.0002537629,0.00008419454,0.00008990555,0.00001263969,0.00001071962],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9823846,"threshold_uncertainty_score":0.4933695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02933964441098832,"score_gpt":0.3677522965922025,"score_spread":0.3384126521812142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}