{"id":"W2204782065","doi":"10.1136/bmj.h3444","title":"The secret realm of phase I trials in healthy volunteers","year":2015,"lang":"en","type":"letter","venue":"BMJ","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Transparency (behavior); Medicine; Clinical trial; Realm; Phase (matter); Volunteer; Pharmacology; Computer security; Pathology; Law; Political science; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.03826099,0.0007991909,0.001222031,0.001122288,0.00592741,0.007750097,0.002716998,0.08108142,0.01026257],"category_scores_gemma":[0.155806,0.001457629,0.001893675,0.001232998,0.01228394,0.01139805,0.004007944,0.05981497,0.01053649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006019167,"about_ca_system_score_gemma":0.01021097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003040222,"about_ca_topic_score_gemma":0.004350673,"domain_scores_codex":[0.9640948,0.01717519,0.003628941,0.003257242,0.01028075,0.00156312],"domain_scores_gemma":[0.8887329,0.07789641,0.00658707,0.006138268,0.009627526,0.0110179],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000119032,0.00006915472,0.001277201,0.0001711247,0.00002348623,0.002956441,0.0006587897,0.00009829328,0.0005025204,0.01753956,0.9532103,0.02337399],"study_design_scores_gemma":[0.00016956,0.0001319634,0.001335034,0.000750236,0.00002126469,0.002925534,0.0005575796,0.0005026536,0.0003398249,0.04491653,0.9482833,0.00006652956],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002788384,0.001117278,0.0002530002,0.9905533,0.004776254,0.00002099723,0.0000162639,0.00001913016,0.002964885],"genre_scores_gemma":[0.003143956,0.000757079,0.0004210594,0.9782801,0.01458585,0.00004830009,0.00001219714,0.00001778704,0.002733676],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.961739,"threshold_uncertainty_score":0.2023458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7189216865534829,"score_gpt":0.6730520041543611,"score_spread":0.04586968239912181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}