{"id":"W2204950130","doi":"10.1016/j.atherosclerosis.2015.12.032","title":"Characterization of the NPC1L1 gene and proteome from an exceptional responder to ezetimibe","year":2015,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute; McGill University; Jewish General Hospital","funders":"National Research Council Canada","keywords":"Ezetimibe; Cholesterol; Chemistry; Biochemistry; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005903,0.000263277,0.0002612725,0.0002288503,0.000203511,0.0002773014,0.0002521555,0.0002730583,0.001092736],"category_scores_gemma":[0.0002707183,0.0001294211,0.0002936795,0.0001526034,0.0002096063,0.000165897,0.0002194335,0.0005732084,0.0005100053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00022738,"about_ca_system_score_gemma":0.0001428095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007197579,"about_ca_topic_score_gemma":0.0007515434,"domain_scores_codex":[0.999917,0.000005369641,0.000007192641,0.00002225578,0.00002771222,0.00002048381],"domain_scores_gemma":[0.9998621,0.0000413983,0.00002336084,0.00002123877,0.00001743897,0.00003452084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001100094,0.000008033741,0.0003252591,0.00001078817,0.000006144518,0.0003950971,0.00001586798,0.00001675978,0.9986078,0.00003563165,0.00005820063,0.0004105009],"study_design_scores_gemma":[0.00002747197,0.0001875257,0.05969305,0.000006860346,0.00007896658,0.005424924,0.0001678342,0.001939576,0.9238948,0.0002769362,0.008282385,0.00001967072],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994303,0.0006614865,0.002093453,0.0002859996,0.00007529321,0.00001797999,0.001717876,0.00006128649,0.0007836624],"genre_scores_gemma":[0.9868349,0.0006562352,0.002475164,0.0002242758,0.00005229182,0.00004323192,0.004880811,0.00008051007,0.00475237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092736,"threshold_uncertainty_score":0.003655553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02282781062784242,"score_gpt":0.2410538962112569,"score_spread":0.2182260855834144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}