{"id":"W2205249602","doi":"10.1093/cid/civ963","title":"Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe","year":2015,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; AIDS Fondet; Ministry of Education and Science; Vetenskapsrådet; Fonds National de la Recherche Luxembourg; Ministry of Health, British Columbia; Istituto Superiore di Sanità; Research Promotion Foundation; Vlaamse regering; European Commission; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Medicine; Drug resistance; Human immunodeficiency virus (HIV); Transmission (telecommunications); Drug; Second line; Current (fluid); Virology; First line; Pharmacology; Internal medicine; Microbiology; Biology; Telecommunications","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006042386,0.0001722701,0.0005285705,0.0000770154,0.00005159445,0.000009505809,0.00005721829,0.00004786775,0.00001502455],"category_scores_gemma":[0.001734328,0.00009503149,0.00011971,0.0003004944,0.0003021653,0.0000329827,0.00003201343,0.0002206757,0.00001800925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004343715,"about_ca_system_score_gemma":0.0001442492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003422777,"about_ca_topic_score_gemma":0.00002721945,"domain_scores_codex":[0.9983513,0.0004068416,0.0005356321,0.0002953045,0.0002521288,0.0001587955],"domain_scores_gemma":[0.9978003,0.0013892,0.0001249383,0.0002625245,0.0001204511,0.0003025794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004237586,0.002281777,0.9521113,0.0002613413,0.0001088986,0.00005908306,0.0003317946,0.00001521447,0.000001114064,0.0002267361,0.02828959,0.01207554],"study_design_scores_gemma":[0.06762752,0.0015798,0.8006789,0.003057105,0.001156328,0.00000650324,0.00002689118,0.0005527702,0.0001696571,0.00113186,0.1236671,0.0003455806],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840129,0.004498262,0.00006068462,0.00804403,0.0002399191,0.00106869,0.00002428477,0.00009646788,0.001954739],"genre_scores_gemma":[0.9952477,0.001765246,0.00001290669,0.0001226892,0.0001026787,0.00005779926,0.00005486037,0.00001779143,0.002618351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1514324,"threshold_uncertainty_score":0.3875271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02669661684177919,"score_gpt":0.3334869405195758,"score_spread":0.3067903236777966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}