{"id":"W2205542261","doi":"10.1186/s12864-015-2264-z","title":"Epigenetic modification with trichostatin A does not correct specific errors of somatic cell nuclear transfer at the transcriptomic level; highlighting the non-random nature of oocyte-mediated reprogramming errors","year":2016,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Academic Center for Education, Culture and Research; Royan Institute; Université Laval","keywords":"Reprogramming; Biology; Epigenetics; Somatic cell; Trichostatin A; Somatic cell nuclear transfer; Oocyte; Genetics; Computational biology; Transcriptome; Epigenomics; Epigenesis; DNA methylation; Cell; Embryo; Gene; Histone; Gene expression; Histone deacetylase; Embryogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537259,0.0002143371,0.0002331227,0.0001550209,0.0001050463,0.0002658795,0.0001806217,0.0001850404,0.001456292],"category_scores_gemma":[0.0002865875,0.00007797722,0.0003325875,0.0001837341,0.0002761958,0.0001459214,0.0001980216,0.0003708706,0.0002713698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001902924,"about_ca_system_score_gemma":0.0002431111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005236182,"about_ca_topic_score_gemma":0.0009492546,"domain_scores_codex":[0.9997488,0.00002781019,0.00003079955,0.00006509249,0.00008942939,0.00003818555],"domain_scores_gemma":[0.9997376,0.00006806481,0.00008674552,0.00005368578,0.00002969338,0.00002426958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000256934,0.000004265035,0.0002808794,0.00001588558,0.000004099055,0.00002088879,0.000003546043,0.0000204985,0.9989446,0.00002128365,0.00001066108,0.0006477078],"study_design_scores_gemma":[0.000003726843,0.0001438773,0.01182833,0.000003214456,0.00002044148,0.0002229381,0.00002226853,0.0004927538,0.9859279,0.00002951975,0.00130255,0.000002407224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851357,0.0007366663,0.01066589,0.0001295928,0.00006379126,0.00004623746,0.001045876,0.0001393875,0.00203686],"genre_scores_gemma":[0.9916632,0.0005846844,0.004562327,0.00008616342,0.00001209603,0.00004571682,0.001280027,0.00004902127,0.001716873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001456292,"threshold_uncertainty_score":0.004871786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02840101213932628,"score_gpt":0.244839747213157,"score_spread":0.2164387350738307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}