{"id":"W2205605114","doi":"10.1016/j.plipres.2015.07.001","title":"CTP:phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesis","year":2015,"lang":"en","type":"review","venue":"Progress in Lipid Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Phosphocholine; Membrane curvature; Biogenesis; Biochemistry; Enzyme; Lipogenesis; Phosphatidylcholine; Chemistry; Cell biology; Phospholipid; Biology; Membrane; Lipid metabolism; Lipid bilayer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007721724,0.0003846219,0.000940503,0.0003503728,0.0001120648,0.00006108414,0.0004213554,0.000601545,0.00002256712],"category_scores_gemma":[0.0002459535,0.0003141496,0.0001956456,0.0004803581,0.0005448751,0.00001403605,0.0001606594,0.0002678561,9.911953e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005074092,"about_ca_system_score_gemma":0.0006466814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002223641,"about_ca_topic_score_gemma":0.00005322949,"domain_scores_codex":[0.9968607,0.0004842887,0.0007107315,0.0008766167,0.0005306771,0.0005369216],"domain_scores_gemma":[0.997943,0.00007422121,0.0001787302,0.0007808558,0.0007218317,0.0003013526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001212567,0.0004085748,0.0006413712,0.02956788,0.0003033679,0.00000855378,0.00006147012,0.00002544248,0.002787572,0.0004990104,0.001077447,0.9634067],"study_design_scores_gemma":[0.002369741,0.001346217,0.0001453437,0.002078293,0.0003593469,0.0000333779,0.00005227627,0.00008596577,0.01453528,0.000414579,0.9779385,0.0006410973],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01838431,0.9786121,0.00006013825,0.00002797687,0.0001906966,0.00172447,0.0009652649,0.0000122917,0.00002276848],"genre_scores_gemma":[0.03355553,0.9605291,0.0008248467,0.000007850029,0.0008093759,0.0004730044,0.003569013,0.00009648249,0.0001348321],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9768611,"threshold_uncertainty_score":0.999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05379233034590391,"score_gpt":0.3882073050997525,"score_spread":0.3344149747538486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}