{"id":"W2206039558","doi":"10.1016/j.cyto.2015.12.007","title":"Negative regulation of the hepatic fibrogenic response by suppressor of cytokine signaling 1","year":2015,"lang":"en","type":"article","venue":"Cytokine","topic":"Liver physiology and pathology","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Cancer Research Society","keywords":"Suppressor of cytokine signaling 1; Fibrosis; Myofibroblast; Hepatic stellate cell; Cytokine; Hepatic fibrosis; Extracellular matrix; SOCS3; Chemistry; Signal transduction; Biology; Cancer research; Cell biology; Endocrinology; Internal medicine; Immunology; Medicine; STAT3; Suppressor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004217075,0.0001019231,0.0003215582,0.00005271234,0.00002876616,0.000001069871,0.0001118027,0.0001112757,0.0000783778],"category_scores_gemma":[0.0006780768,0.00006845665,0.00009152777,0.0002134673,0.0002699264,0.00004434521,0.00005992565,0.0001255866,0.000008274725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003021867,"about_ca_system_score_gemma":0.0001207151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003543152,"about_ca_topic_score_gemma":0.000001680233,"domain_scores_codex":[0.9988825,0.0003648091,0.0002977799,0.0001519927,0.0001714736,0.0001314393],"domain_scores_gemma":[0.9988099,0.0003392465,0.0002194473,0.0003592855,0.00021218,0.00005988869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004033695,0.00008855482,0.007755865,0.00004297107,0.00006022742,0.000003713115,0.000981953,0.00006635053,0.9848548,0.0001162106,0.001948362,0.00004730309],"study_design_scores_gemma":[0.001770084,0.0006770047,0.07074978,0.00008732976,0.0001141945,0.00003763552,0.00008147615,0.0002083385,0.9245455,0.001227516,0.0004414562,0.00005969642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982734,0.0001560525,0.00008828085,0.0007561326,0.0001033876,0.0002639882,0.00008164822,0.00001486622,0.0002622814],"genre_scores_gemma":[0.998866,0.000003118272,0.0003601228,0.0001597997,0.00004285006,0.000007808127,0.00003400014,0.00001194436,0.0005143277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06299392,"threshold_uncertainty_score":0.2791581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.025324059583905,"score_gpt":0.2690304373727697,"score_spread":0.2437063777888647,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}