{"id":"W2206535788","doi":"10.1093/hmg/ddv399","title":"Disruption of murine<i>Adamtsl4</i>results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McGill University; National Cancer Institute; National Institutes of Health; Marfan Foundation; Case Western Reserve University; U.S. Department of Veterans Affairs; Jackson Laboratory; Research to Prevent Blindness; National Eye Institute; Cleveland Clinic; Foundation Fighting Blindness","keywords":"Biology; Retinal pigment epithelium; Thrombospondin; Phenotype; Cell biology; Lens (geology); Retina; ADAMTS; Retinal; Genetics; Molecular biology; Gene; Metalloproteinase; Matrix metalloproteinase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002169303,0.00013061,0.0001929315,0.00007311479,0.00002267128,0.0000103901,0.00006935518,0.00007060539,0.00001410345],"category_scores_gemma":[0.00003952556,0.0000990263,0.00004524027,0.00009460797,0.00007459802,0.0000158857,0.000061627,0.0001370812,0.000005077721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004801273,"about_ca_system_score_gemma":0.00003075449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002491207,"about_ca_topic_score_gemma":0.0003225526,"domain_scores_codex":[0.9988182,0.0001165723,0.0003659153,0.0002209547,0.0003104483,0.0001679189],"domain_scores_gemma":[0.9994999,0.00002163097,0.0000987709,0.000259534,0.00005510573,0.00006509315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000943983,0.0008412368,0.7230831,0.0001260234,0.00008954993,0.0001547641,0.00512948,0.0004053683,0.2656043,0.0002684558,0.0002709339,0.003082709],"study_design_scores_gemma":[0.00305566,0.0003208678,0.9859435,0.000143931,0.00008296342,0.000005549186,0.0003220217,0.0005171782,0.008339016,0.0006139976,0.0005481772,0.0001071657],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965007,0.001817337,0.0001960267,0.0006542188,0.00004080364,0.000397277,0.00000961849,0.000006621517,0.0003773776],"genre_scores_gemma":[0.998924,0.0001473527,0.0005737229,0.0001343882,0.0000302232,0.00001193542,0.0001170212,0.00001501931,0.00004633006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2628603,"threshold_uncertainty_score":0.4038175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02206252865270237,"score_gpt":0.2708890130127811,"score_spread":0.2488264843600787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}