{"id":"W2206903933","doi":"10.1158/1078-0432.ccr-15-1853","title":"Combined Antitumor Therapy with Metronomic Topotecan and Hypoxia-Activated Prodrug, Evofosfamide, in Neuroblastoma and Rhabdomyosarcoma Preclinical Models","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Topotecan; Neuroblastoma; Rhabdomyosarcoma; Cancer research; Medicine; In vivo; Pharmacology; Chemotherapy; Cell culture; Internal medicine; Sarcoma; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002321928,0.000566395,0.0007692922,0.0003524952,0.0001397116,0.0001931342,0.0004080581,0.0003118559,0.0007620343],"category_scores_gemma":[0.00008132141,0.0001536605,0.0003386989,0.0001930239,0.0001909568,0.00026469,0.000170196,0.0006030664,0.0001418161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005000097,"about_ca_system_score_gemma":0.0005216671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001177909,"about_ca_topic_score_gemma":0.003947133,"domain_scores_codex":[0.9998521,0.00002756432,0.00001053631,0.00003087287,0.00004328894,0.00003571016],"domain_scores_gemma":[0.9999373,0.000006761549,0.00001629958,0.000008193468,0.000008146579,0.00002327314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003404035,0.002200611,0.001013503,0.0002408225,0.0001216602,0.0001382956,0.00004199784,0.001192533,0.9743853,0.0001497998,0.0002686226,0.01684272],"study_design_scores_gemma":[0.0008186956,0.04385604,0.008384986,0.00002094978,0.0002653044,0.0005861112,0.00004189495,0.002328171,0.9397625,0.00004937646,0.003870333,0.00001563264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956567,0.002068426,0.0008740875,0.00004790744,0.00003981747,0.0001582734,0.000204411,0.00003608065,0.0009143287],"genre_scores_gemma":[0.9943358,0.001541574,0.001977483,0.00002516989,0.00001713407,0.0001541909,0.0004997872,0.00000852122,0.001440319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177909,"threshold_uncertainty_score":0.003627837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1878130194153975,"score_gpt":0.4377215972499732,"score_spread":0.2499085778345757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}