{"id":"W2207297826","doi":"10.1002/eji.201546005","title":"Interleukin‐1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset","year":2015,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Euskal Herriko Unibertsitatea; National Institutes of Health; Technische Universität München; Novo Nordisk; Yale University; University of Toronto; Varsinais-Suomen Sairaanhoitopiiri; National Center for Advancing Translational Sciences; Joslin Diabetes Center; Leids Universitair Medisch Centrum; Universität Ulm; Universiteit Leiden; University of Bristol; Cedars-Sinai Medical Center; U.S. National Library of Medicine; University of Pittsburgh; University of Minnesota; University of Miami; Vanderbilt University; George Washington University; University of South Florida; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; American Diabetes Association; University of Washington; Juvenile Diabetes Research Foundation International","keywords":"Canakinumab; Medicine; Antagonism; Clinical trial; Immune system; Inflammation; Immunology; Interleukin; Internal medicine; Cytokine; Clinical endpoint; Pharmacology; Oncology; Bioinformatics; Disease; Receptor; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004154701,0.0002895319,0.0006141256,0.0001962586,0.0002178136,0.0007330253,0.0001463622,0.0002713791,0.0007596134],"category_scores_gemma":[0.00339301,0.000131496,0.0002128417,0.0002251751,0.0002972026,0.0003164312,0.000204136,0.0007207852,0.0001453654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184711,"about_ca_system_score_gemma":0.0004087224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009150264,"about_ca_topic_score_gemma":0.0004587524,"domain_scores_codex":[0.9977495,0.001323765,0.0001757003,0.0002396694,0.0003241092,0.0001873063],"domain_scores_gemma":[0.9981251,0.0007817225,0.0006684355,0.0001346126,0.0001093286,0.0001806669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1192642,0.004122503,0.07550151,0.001164444,0.0007640255,0.0001420507,0.0006188906,0.001299099,0.5775223,0.0004480018,0.001269776,0.2178831],"study_design_scores_gemma":[0.009134697,0.1741661,0.5460349,0.0002031676,0.001992698,0.0007883302,0.0004613982,0.005702425,0.247934,0.001405976,0.01209657,0.00007973239],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945014,0.003033847,0.0008290992,0.0001916388,0.00005403061,0.0001143379,0.0001234255,0.0000290625,0.001123024],"genre_scores_gemma":[0.9977275,0.0005491374,0.0008398425,0.0001359817,0.00005345565,0.0001212532,0.0001132963,0.000007536208,0.0004520296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004154701,"threshold_uncertainty_score":0.02197242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03991659910112435,"score_gpt":0.2917710175408439,"score_spread":0.2518544184397196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}