{"id":"W2207297826","doi":"10.1002/eji.201546005","title":"Interleukin‐1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset","year":2015,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Euskal Herriko Unibertsitatea; National Institutes of Health; Technische Universität München; Novo Nordisk; Yale University; University of Toronto; Varsinais-Suomen Sairaanhoitopiiri; National Center for Advancing Translational Sciences; Joslin Diabetes Center; Leids Universitair Medisch Centrum; Universität Ulm; Universiteit Leiden; University of Bristol; Cedars-Sinai Medical Center; U.S. National Library of Medicine; University of Pittsburgh; University of Minnesota; University of Miami; Vanderbilt University; George Washington University; University of South Florida; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; American Diabetes Association; University of Washington; Juvenile Diabetes Research Foundation International","keywords":"Canakinumab; Medicine; Antagonism; Clinical trial; Immune system; Inflammation; Immunology; Interleukin; Internal medicine; Cytokine; Clinical endpoint; Pharmacology; Oncology; Bioinformatics; Disease; Receptor; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004251233,0.0001880591,0.0004302173,0.00005271707,0.0001132246,0.00005014706,0.000368726,0.00006256621,0.00001336955],"category_scores_gemma":[0.003991921,0.0001162844,0.0001859536,0.00008600656,0.0003079862,0.00001308822,0.0001941162,0.0003294625,0.00001919505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003882517,"about_ca_system_score_gemma":0.0002432738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.956856e-7,"about_ca_topic_score_gemma":0.000004465342,"domain_scores_codex":[0.9946398,0.003815894,0.000897215,0.0001880781,0.000146953,0.0003121221],"domain_scores_gemma":[0.9978743,0.0001726526,0.001066302,0.000258428,0.0004548714,0.0001735086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01070415,0.0008372869,0.3401061,0.00002269341,0.009140559,0.0006927292,0.000856874,0.001286235,0.6085495,0.00001598478,0.02308322,0.004704669],"study_design_scores_gemma":[0.02595705,0.009339014,0.81822,0.0003923059,0.0008665783,0.0001167026,0.001207273,0.0001370309,0.1101003,0.0003305149,0.03209819,0.001234967],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947021,0.004046264,0.000009792778,0.0003588321,0.0005723379,0.000110269,0.00003102805,0.00001145739,0.0001579041],"genre_scores_gemma":[0.9984339,0.0005252342,0.00001773887,0.0003142523,0.0001537322,0.000001263068,0.00007680035,0.0000412081,0.0004359122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4984491,"threshold_uncertainty_score":0.477899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03991659910112435,"score_gpt":0.2917710175408439,"score_spread":0.2518544184397196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}