{"id":"W2207384520","doi":"10.1371/journal.pgen.1005754","title":"Gene Regulatory Mechanisms Underlying the Spatial and Temporal Regulation of Target-Dependent Gene Expression in Drosophila Neurons","year":2015,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia; Canadian Institutes of Health Research; Killam Trusts; Echo Foundation","keywords":"Enhancer; Biology; Transcription factor; Repressor; Regulation of gene expression; Cell biology; Gene expression; Gene; Genetics; Response element; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002754274,0.000132172,0.0001751713,0.00009559627,0.0001251944,0.0000138498,0.0002684543,0.0001224469,0.00001217273],"category_scores_gemma":[0.0001848396,0.0001011793,0.00002683478,0.0001383168,0.0002938118,0.00006456525,0.000250412,0.0002488524,0.000005413764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000204491,"about_ca_system_score_gemma":0.00007917859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006469013,"about_ca_topic_score_gemma":0.000007554892,"domain_scores_codex":[0.9982854,0.0005268352,0.0002750771,0.0003782825,0.0002790059,0.0002554751],"domain_scores_gemma":[0.999217,0.0001578153,0.0001191963,0.0003737837,0.00004743583,0.00008481988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008114466,0.00008065988,0.001266057,0.000007364202,0.000002096988,0.000006873978,0.0001946464,0.0005149788,0.9975295,0.0001739184,0.00001736405,0.0001254078],"study_design_scores_gemma":[0.0004195221,0.0002741928,0.02127625,0.000009708693,0.00000554235,0.0000188024,0.00002338866,0.006260191,0.9570944,0.01452204,0.000005418104,0.00009050334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998679,0.0001282565,0.0003980618,0.0001886176,0.0001661936,0.000330638,0.00001195527,0.00002040677,0.00007683275],"genre_scores_gemma":[0.9990775,0.00004935164,0.0005808547,0.0001704582,0.0000350125,0.0000178598,0.000005785463,0.00001934643,0.00004380448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04043504,"threshold_uncertainty_score":0.4125971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09310797966492053,"score_gpt":0.2963030382639416,"score_spread":0.203195058599021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}