{"id":"W2207448814","doi":"10.4049/jimmunol.1501529","title":"Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance","year":2015,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Insulin resistance; Caspase; Inflammation; Inflammasome; Biology; Caspase 2; Adipose tissue; Caspase 3; Endocrinology; Internal medicine; Caspase 1; Metabolic syndrome; Systemic inflammation; Apoptosis; Obesity; Immunology; Medicine; Genetics; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002466135,0.0004044345,0.0003827244,0.0002831392,0.0001063923,0.0003032277,0.0002170327,0.0002833615,0.001518181],"category_scores_gemma":[0.0002665198,0.000100513,0.0003166765,0.0001615587,0.0002395548,0.0002224087,0.0001951533,0.001120096,0.0003081374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001405668,"about_ca_system_score_gemma":0.0001928554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001857195,"about_ca_topic_score_gemma":0.0004118557,"domain_scores_codex":[0.9998376,0.0000380137,0.00002266864,0.00002773162,0.00003398316,0.00003999932],"domain_scores_gemma":[0.9998349,0.00002222714,0.0000515796,0.00002213436,0.0000221647,0.0000469884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002209515,0.000619824,0.0007260906,0.0002045448,0.00004818623,0.0000818819,0.00002192828,0.0002344237,0.9702191,0.0002802943,0.0003316929,0.02502241],"study_design_scores_gemma":[0.001079471,0.007637776,0.01447827,0.00006444591,0.0001409728,0.001201588,0.00007169537,0.002801648,0.9615483,0.0006764907,0.01028283,0.00001655953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832544,0.009601516,0.003394685,0.0005734786,0.0001455874,0.00004587945,0.0002122719,0.000214514,0.002557745],"genre_scores_gemma":[0.9916467,0.003470064,0.00235567,0.0001151568,0.00003160311,0.00003483258,0.0002684513,0.0000222273,0.002055355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001518181,"threshold_uncertainty_score":0.005078852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218521850293694,"score_gpt":0.222440691095128,"score_spread":0.210255472592191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}