{"id":"W2207992373","doi":"10.1016/j.jchf.2014.05.007","title":"Rationale and Design of the GUIDE-IT Study","year":2014,"lang":"en","type":"article","venue":"JACC Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; Roche","keywords":"Medicine; Clinical endpoint; Heart failure; Ejection fraction; Natriuretic peptide; Guideline; Observational study; Randomized controlled trial; Internal medicine; Intensive care medicine; Cardiology; Prospective cohort study; Biomarker; Clinical trial; Emergency medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004874815,0.0001034402,0.0002145195,0.00004575112,0.00008656496,0.00001366358,0.00005116505,0.00004034494,0.0001581703],"category_scores_gemma":[0.0001266011,0.00006276498,0.0000513037,0.0001244249,0.00004323587,0.00004802385,0.00006023261,0.00007815933,0.00003939493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001810645,"about_ca_system_score_gemma":0.00005039545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004224772,"about_ca_topic_score_gemma":0.00005697169,"domain_scores_codex":[0.9990882,0.0001334136,0.0002177648,0.0001754984,0.000252746,0.0001323731],"domain_scores_gemma":[0.9993795,0.0001105559,0.00003730268,0.0003412823,0.00006465936,0.00006674142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005404569,0.0005252431,0.1363871,0.00006233907,0.0001387177,0.000003738789,0.0008940797,0.00003370086,0.00286946,0.0008000285,0.856656,0.001575583],"study_design_scores_gemma":[0.001881237,0.0005923308,0.08314496,0.00004729995,0.0001417996,0.00001477626,0.0006807831,0.0003054466,0.0006652141,0.00009324134,0.9123538,0.00007912282],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4963984,0.000163597,0.007432318,0.4804402,0.000348083,0.01051642,0.000006638747,0.0001598686,0.004534559],"genre_scores_gemma":[0.9734195,0.00000371593,0.01766867,0.001733054,0.0001151639,0.00007772104,0.000003306255,0.00001391363,0.00696494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4787071,"threshold_uncertainty_score":0.2559482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0256884309420738,"score_gpt":0.2820365457725795,"score_spread":0.2563481148305057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}