{"id":"W2208086566","doi":"10.1016/j.cjca.2015.12.015","title":"Nicotine Induces Cardiomyocyte Hypertrophy Through TRPC3-Mediated Ca2+/NFAT Signalling Pathway","year":2015,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"NFAT; TRPC3; TRPC; Calcineurin; Nicotine; Muscle hypertrophy; Medicine; Endocrinology; Internal medicine; Cell biology; Downregulation and upregulation; Intracellular; Pharmacology; Biology; Biochemistry; Transplantation; Transient receptor potential channel","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005373198,0.0002236676,0.0006857628,0.0003056065,0.0001764019,0.00005335523,0.0004725967,0.0002406809,0.00002654957],"category_scores_gemma":[0.001153837,0.0001760365,0.0003057644,0.0003648438,0.000321154,0.0002429312,0.0000270389,0.0005374995,0.00007189534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002326854,"about_ca_system_score_gemma":0.001975122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007370177,"about_ca_topic_score_gemma":0.0002168536,"domain_scores_codex":[0.9977996,0.0004846267,0.0005128454,0.0002779454,0.0002904439,0.0006345156],"domain_scores_gemma":[0.9980196,0.0002115624,0.0002860975,0.000151929,0.0003268281,0.001003983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002847099,0.00001563805,0.001627836,0.00003609227,0.0003652569,0.003087951,0.006678249,0.07685667,0.8270438,0.001290113,0.07715044,0.005563203],"study_design_scores_gemma":[0.0017933,0.0008063543,0.00009871332,0.0000562135,0.00006834911,0.002638677,0.001197847,0.0000929665,0.2671111,0.0009663602,0.7246742,0.0004959745],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781545,0.001358436,0.001079,0.001336348,0.007363562,0.0001328547,0.00005644123,0.00002101623,0.01049789],"genre_scores_gemma":[0.9956678,0.0001493335,0.0000940756,0.0007542238,0.003138155,0.000002765474,0.000003936557,0.00003234207,0.0001573413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6475237,"threshold_uncertainty_score":0.7178561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07193145884960199,"score_gpt":0.251331063973443,"score_spread":0.179399605123841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}