{"id":"W2208164594","doi":"10.1093/mutage/gev070","title":"Genotoxicity of flubendazole and its metabolites<i>in vitro</i>and the impact of a new formulation on<i>in vivo</i>aneugenicity","year":2015,"lang":"en","type":"article","venue":"Mutagenesis","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada; Drugs for Neglected Diseases initiative; Bill and Melinda Gates Foundation","keywords":"Ames test; Micronucleus test; Genotoxicity; Pharmacology; In vivo; Metabolite; Micronucleus; Biology; Chemistry; Toxicity; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003290644,0.0001228405,0.0004044509,0.0001548758,0.00001616189,0.00000640176,0.00005058214,0.00005443491,0.00002939993],"category_scores_gemma":[0.0002387898,0.00007434378,0.0001036485,0.0002222485,0.00005891992,0.0000618656,0.000035918,0.00007488037,0.000002205623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007983747,"about_ca_system_score_gemma":0.0002467347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002390109,"about_ca_topic_score_gemma":0.00004790742,"domain_scores_codex":[0.9990012,0.00009523438,0.0002466379,0.0001665224,0.0002807641,0.0002096076],"domain_scores_gemma":[0.9992855,0.0001401881,0.00006607047,0.0001822761,0.00006192529,0.0002640024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03881712,0.002830991,0.3290698,0.0004713777,0.001080089,0.0002009977,0.005217932,0.001405118,0.5923066,0.001836059,0.0002481071,0.02651577],"study_design_scores_gemma":[0.01262131,0.0004155033,0.6033357,0.00004845676,0.000146641,0.00001428369,0.0000710891,0.006889347,0.3758565,0.0004849654,0.00002698648,0.00008915961],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944838,0.00410335,0.00001348169,0.0001507746,0.000008843665,0.0006097169,0.00008309329,0.000005469932,0.0005415262],"genre_scores_gemma":[0.9994553,0.0002376407,0.00008979782,0.00003782364,0.00001912599,0.00001888385,0.000007964058,0.000008863512,0.0001245789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2742659,"threshold_uncertainty_score":0.3613146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0399134318887255,"score_gpt":0.3455502532159158,"score_spread":0.3056368213271903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}