{"id":"W2208298605","doi":"10.1038/mt.2015.190","title":"Silent IL2RG Gene Editing in Human Pluripotent Stem Cells","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Sunnybrook Hospital; University of Toronto; University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Induced pluripotent stem cell; Biology; Chromatin; Homologous recombination; Genetics; Gene targeting; Transgene; Genome editing; Gene knockin; Selectable marker; Human artificial chromosome; Gene; Retrotransposon; CRISPR; Cell biology; Genome; Embryonic stem cell; Transposable element; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002106669,0.0001728048,0.0001371669,0.00005516727,0.00002928359,0.00002329355,0.0001792723,0.0001090082,0.000007446039],"category_scores_gemma":[0.000004539943,0.0001751597,0.00008049014,0.00008100945,0.0000233838,0.000001984243,0.00006228324,0.00009083439,0.000009734865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000026197,"about_ca_system_score_gemma":0.00003023889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002758226,"about_ca_topic_score_gemma":0.000009414525,"domain_scores_codex":[0.9989782,0.00004997911,0.0002032632,0.0003128069,0.0001709349,0.0002848193],"domain_scores_gemma":[0.9994515,0.000002223543,0.00003989684,0.0003385711,0.00004838905,0.0001194273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001918845,0.00005079614,0.0002205513,0.000004352174,0.00002460534,0.00003289446,0.0001330551,0.007546382,0.9881886,0.00001938234,0.0002358741,0.00352428],"study_design_scores_gemma":[0.001082877,0.0002121841,0.0002032325,0.00000885267,0.000003380551,0.000008229172,0.0001032554,0.0001700709,0.9779712,0.00003913585,0.01999928,0.0001983224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978776,0.004134282,0.01614724,0.00007395993,0.0002549916,0.0001969864,0.000003983527,0.00001906809,0.0003935374],"genre_scores_gemma":[0.9983169,0.0001456988,0.0006618591,0.0002779264,0.0002425134,0.00002750907,0.00003078405,0.0000401325,0.0002566217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01976341,"threshold_uncertainty_score":0.7142807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01594564522027632,"score_gpt":0.2857658430656295,"score_spread":0.2698201978453532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}