{"id":"W2208379272","doi":"10.1186/2051-1426-3-s2-p160","title":"Pembrolizumab (MK-3475) in combination with lenalidomide and low-dose dexamethasone for relapsed/refractory multiple myeloma (RRMM): KEYNOTE-023","year":2015,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Lenalidomide; Pembrolizumab; Dexamethasone; Medicine; Multiple myeloma; Oncology; Internal medicine; Cancer research; Pharmacology; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004368367,0.000463207,0.000654856,0.0003025647,0.0003521092,0.0003564794,0.0003943511,0.0005393786,0.005487538],"category_scores_gemma":[0.0002609113,0.0001718278,0.0004430265,0.0002023061,0.0001492972,0.0002343067,0.0001850886,0.001031247,0.0008478582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004923569,"about_ca_system_score_gemma":0.000424236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001691013,"about_ca_topic_score_gemma":0.004993124,"domain_scores_codex":[0.9998837,0.00003418597,0.00001566444,0.00001353634,0.00002084007,0.00003216164],"domain_scores_gemma":[0.9999278,0.00001585589,0.000008019833,0.000002083863,0.000008163339,0.00003821035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.07805106,0.005050125,0.005307427,0.001346856,0.0006587908,0.006398716,0.0001729832,0.001085481,0.07796521,0.0008294701,0.08999329,0.7331405],"study_design_scores_gemma":[0.09423455,0.1391899,0.2034692,0.00119727,0.00335463,0.02301679,0.0004274274,0.007910256,0.06504734,0.001242214,0.4607179,0.0001925049],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7692603,0.1507299,0.001969542,0.01769731,0.005659684,0.001412458,0.001283142,0.0005017419,0.05148592],"genre_scores_gemma":[0.9295858,0.03625712,0.002948041,0.003203547,0.00357838,0.0002656313,0.0009866511,0.00004523461,0.02312967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005487538,"threshold_uncertainty_score":0.01835763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04112271902787046,"score_gpt":0.3538140881746188,"score_spread":0.3126913691467483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}