{"id":"W2208622692","doi":"10.1016/j.cellimm.2015.12.008","title":"Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice","year":2015,"lang":"en","type":"article","venue":"Cellular Immunology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Harvard Digestive Diseases Center, Harvard University; National Institutes of Health; Biogen","keywords":"Immunogenicity; Recombinant DNA; Antibody; Biology; Immune system; Immune tolerance; Fusion protein; Immunology; Receptor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003440881,0.0002458224,0.0005358495,0.00020956,0.0001051242,0.00002302917,0.0002186014,0.0002638664,0.0001238424],"category_scores_gemma":[0.0001408808,0.0001995254,0.00007874599,0.0002715266,0.0003436018,0.0001064493,0.0002752986,0.0006198646,0.0001689759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001077832,"about_ca_system_score_gemma":0.0002128849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105608,"about_ca_topic_score_gemma":0.00004569154,"domain_scores_codex":[0.9981384,0.0002084021,0.0004140576,0.0004466351,0.0002666466,0.0005258495],"domain_scores_gemma":[0.9992539,0.000057484,0.0001006127,0.0002984098,0.0001207746,0.000168823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002065709,0.0002641764,0.002446257,0.00007058802,0.00006062247,0.0002002959,0.001013552,5.452515e-7,0.9845185,0.0001404255,0.0001228215,0.009096514],"study_design_scores_gemma":[0.004196662,0.001611839,0.03087857,0.0003423711,0.00002321024,0.0003529492,0.0006084938,0.0001750569,0.9406592,0.0007867337,0.01995216,0.0004127657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772114,0.01821567,0.000004255418,0.002775354,0.0003425008,0.0006712758,0.000009493288,0.00003674656,0.000733345],"genre_scores_gemma":[0.9938992,0.0007402616,0.0003392173,0.0001067396,0.00009197521,0.00005297321,0.00004561631,0.00002369964,0.004700354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0438593,"threshold_uncertainty_score":0.8136408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0399160662361555,"score_gpt":0.2867148651727877,"score_spread":0.2467987989366321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}