{"id":"W2208858999","doi":"10.1007/s10741-015-9524-5","title":"MELAS syndrome and cardiomyopathy: linking mitochondrial function to heart failure pathogenesis","year":2015,"lang":"en","type":"review","venue":"Heart Failure Reviews","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; Heart and Stroke Foundation of Canada","keywords":"Medicine; Cardiomyopathy; Heart failure; Mitochondrial myopathy; Cardiology; Internal medicine; Mitochondrial disease; Pathogenesis; Myopathy; Lactic acidosis; Dilated cardiomyopathy; Mitochondrion; MELAS syndrome; Mitochondrial DNA; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005480374,0.0009165237,0.001387142,0.001886214,0.0002386978,0.0009854176,0.0008908793,0.001274373,0.003066609],"category_scores_gemma":[0.000894034,0.000221507,0.0003929693,0.001851041,0.0004484896,0.001214857,0.0009342338,0.001847599,0.001374854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004796434,"about_ca_system_score_gemma":0.001013154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008500014,"about_ca_topic_score_gemma":0.001949963,"domain_scores_codex":[0.9998264,0.00002798385,0.00002681021,0.00002819973,0.00007078615,0.00001987267],"domain_scores_gemma":[0.9996202,0.0001628925,0.00006022961,0.00001021322,0.00009707535,0.00004935008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001136189,0.00006743046,0.00031339,0.01204705,0.0001292282,0.0004940967,0.00005013009,0.0003064705,0.002755691,0.002958464,0.0674727,0.9132918],"study_design_scores_gemma":[0.00003861399,0.00007272253,0.001251337,0.004373805,0.0002106039,0.002688613,0.00007622696,0.0001127931,0.0004240323,0.003279311,0.9874405,0.00003156091],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006272268,0.9988534,0.00010701,0.0003300883,0.000284464,0.000002088177,0.00001052994,0.000006114476,0.0003433984],"genre_scores_gemma":[0.0004121237,0.9983484,0.0001532667,0.0002982983,0.0004144037,0.000003113116,0.00002066804,0.000001061776,0.0003487819],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003066609,"threshold_uncertainty_score":0.01025879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03623697008836116,"score_gpt":0.3020072371896263,"score_spread":0.2657702671012652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}