{"id":"W2208858999","doi":"10.1007/s10741-015-9524-5","title":"MELAS syndrome and cardiomyopathy: linking mitochondrial function to heart failure pathogenesis","year":2015,"lang":"en","type":"review","venue":"Heart Failure Reviews","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; Heart and Stroke Foundation of Canada","keywords":"Medicine; Cardiomyopathy; Heart failure; Mitochondrial myopathy; Cardiology; Internal medicine; Mitochondrial disease; Pathogenesis; Myopathy; Lactic acidosis; Dilated cardiomyopathy; Mitochondrion; MELAS syndrome; Mitochondrial DNA; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001143039,0.001023145,0.003550363,0.0003071218,0.0002199,0.0001276328,0.000325902,0.001401389,0.0001099103],"category_scores_gemma":[0.000371808,0.0008546646,0.001243378,0.0005544875,0.00008124508,0.00001487545,0.0003802368,0.0005763905,0.00118464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007328743,"about_ca_system_score_gemma":0.0004331156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001059657,"about_ca_topic_score_gemma":0.00008229822,"domain_scores_codex":[0.9945109,0.001495725,0.001310141,0.001643402,0.00036079,0.0006789766],"domain_scores_gemma":[0.9973326,0.00004883755,0.0003959155,0.001371211,0.0002154967,0.0006359345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008120231,0.00006734167,0.00004948851,0.01097654,0.0002957208,0.00003680247,0.00004271371,0.000003540016,0.006139535,0.00003495219,0.635024,0.3472481],"study_design_scores_gemma":[0.000316726,0.0006284622,0.000003340571,0.003392488,0.0008844724,0.002138649,0.00001210869,2.452188e-7,0.00002116771,0.00000864744,0.9917595,0.0008342172],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003874579,0.9916855,0.00146544,0.0003623646,0.002818277,0.00336342,0.0001268547,0.00005891248,0.0000805216],"genre_scores_gemma":[0.000003394633,0.9786485,0.01370398,0.000815299,0.003567649,0.0009317347,0.001160872,0.0001711975,0.0009973105],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3567355,"threshold_uncertainty_score":0.999895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03623697008836116,"score_gpt":0.3020072371896263,"score_spread":0.2657702671012652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}