{"id":"W2208911155","doi":"10.1002/stem.2258","title":"Brief Report: Common Genetic Variation in Chromosome 10 q22.1 Shows a Strong Sex Bias in Human Embryonic Stem Cell Lines and Directly Controls the Novel Alternative Splicing of Human NODAL which is Associated with XIST Expression in Female Cell Lines","year":2015,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Western University","funders":"Canadian Institutes of Health Research; Ontario Institute for Regenerative Medicine","keywords":"Biology; Embryonic stem cell; Induced pluripotent stem cell; Genetics; Single-nucleotide polymorphism; Alternative splicing; Allele; Gene; Computational biology; Exon; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00124782,0.0003194739,0.0005556907,0.0001879268,0.0000874495,0.00006716874,0.0003453391,0.0002550376,0.000008083952],"category_scores_gemma":[0.00002433161,0.0002559318,0.0000555228,0.0003440888,0.000101076,0.00002127315,0.000269732,0.0003154101,0.000001343393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001344398,"about_ca_system_score_gemma":0.0001662548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001229176,"about_ca_topic_score_gemma":0.006143174,"domain_scores_codex":[0.9970971,0.0004767969,0.0007888387,0.0006919885,0.0004765838,0.0004686921],"domain_scores_gemma":[0.998346,0.0001236977,0.0006139678,0.0005392178,0.000266447,0.0001106293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001215537,0.0003479477,0.0355246,0.0001083802,0.00002730115,0.00005925583,0.001322115,0.002988853,0.9594213,0.000001152537,0.00003490279,0.00004259095],"study_design_scores_gemma":[0.00425297,0.0005721956,0.01767505,0.0003088647,0.00002160492,0.00001069581,0.0007293277,0.003802237,0.9722759,0.000005349104,0.0000501172,0.0002957209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972024,0.0005716674,0.00008118792,0.00004274752,0.00005143474,0.0009616175,0.00006593239,0.000009517756,0.001013484],"genre_scores_gemma":[0.9957538,0.00004459651,0.00006043199,0.00002029485,0.0000818023,0.00006338397,0.00008336502,0.00004833392,0.003844017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01784955,"threshold_uncertainty_score":0.9999893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03672657914401891,"score_gpt":0.285861794883959,"score_spread":0.24913521573994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}