{"id":"W2208911155","doi":"10.1002/stem.2258","title":"Brief Report: Common Genetic Variation in Chromosome 10 q22.1 Shows a Strong Sex Bias in Human Embryonic Stem Cell Lines and Directly Controls the Novel Alternative Splicing of Human NODAL which is Associated with XIST Expression in Female Cell Lines","year":2015,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Western University","funders":"Canadian Institutes of Health Research; Ontario Institute for Regenerative Medicine","keywords":"Biology; Embryonic stem cell; Induced pluripotent stem cell; Genetics; Single-nucleotide polymorphism; Alternative splicing; Allele; Gene; Computational biology; Exon; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003027286,0.0004323188,0.0003577493,0.0004460238,0.0003218576,0.0003786157,0.0003803177,0.001471314,0.008641759],"category_scores_gemma":[0.0008440703,0.0001541757,0.0002427424,0.0003165305,0.0002972656,0.0002143351,0.000315301,0.0005868831,0.002768848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002426808,"about_ca_system_score_gemma":0.0002031804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003956301,"about_ca_topic_score_gemma":0.0003777252,"domain_scores_codex":[0.9996774,0.00005647309,0.00005304726,0.0001228101,0.00005214267,0.0000380286],"domain_scores_gemma":[0.9993399,0.0002301625,0.0001288198,0.00005228897,0.00008949484,0.0001593557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003458432,0.0004835039,0.07042198,0.001688044,0.0004377861,0.2661203,0.0008069904,0.0004062778,0.1437235,0.003053848,0.3205277,0.1888716],"study_design_scores_gemma":[0.000303149,0.002283864,0.1248484,0.0002035982,0.0003737622,0.3445336,0.0006430451,0.0005195516,0.06113486,0.001787468,0.4632385,0.0001301121],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7616724,0.02997756,0.01881623,0.0848803,0.04453781,0.0006014872,0.0200072,0.001484435,0.03802247],"genre_scores_gemma":[0.8669059,0.01399525,0.004786691,0.01133567,0.03756438,0.0001706396,0.01093603,0.0002924967,0.054013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008641759,"threshold_uncertainty_score":0.0289095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03672657914401891,"score_gpt":0.285861794883959,"score_spread":0.24913521573994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}