{"id":"W2209063367","doi":"10.1182/blood.v124.21.712.712","title":"Phase 1b Dose-Escalation Study of Sonidegib (LDE225) in Combination with Ruxolitinib (INC424) in Patients with Myelofibrosis","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ruxolitinib; Medicine; Myelofibrosis; Internal medicine; Smoothened; Oncology; Gastroenterology; Bone marrow; Hedgehog signaling pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009247088,0.001217236,0.001550764,0.0004408185,0.0002934626,0.0007615011,0.0005307131,0.0008286293,0.004608199],"category_scores_gemma":[0.0005604281,0.0005260251,0.00084325,0.0002370641,0.0004701714,0.0006303694,0.0003112291,0.002242683,0.001120735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000809034,"about_ca_system_score_gemma":0.001006214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006988302,"about_ca_topic_score_gemma":0.002021433,"domain_scores_codex":[0.999746,0.0001061417,0.00001419229,0.00005332618,0.00003164816,0.00004866005],"domain_scores_gemma":[0.9997141,0.00003035348,0.00004170958,0.00002032817,0.00002719789,0.0001663261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5963211,0.1053128,0.01237362,0.001052781,0.001910544,0.0004274427,0.0004385939,0.004547521,0.09240342,0.0004106956,0.009691318,0.1751101],"study_design_scores_gemma":[0.5281722,0.4323575,0.02312639,0.00006435996,0.0005795409,0.0005681618,0.00008267214,0.002860849,0.006965266,0.0002953162,0.004880116,0.00004775325],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930646,0.00124186,0.0004259392,0.000367563,0.00006389755,0.001844726,0.0009211524,0.0001248992,0.001945343],"genre_scores_gemma":[0.9907166,0.0007611536,0.001460117,0.0006975944,0.0000623575,0.001745201,0.002001663,0.00002006025,0.002535223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004608199,"threshold_uncertainty_score":0.01541591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009788318639597818,"score_gpt":0.2545714235835682,"score_spread":0.2447831049439704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}