{"id":"W2209349785","doi":"10.1016/j.cell.2015.11.009","title":"Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":606,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Institute of Allergy and Infectious Diseases; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute","keywords":"Biology; Genomics; Pathogenicity; Computational biology; Cell; Genetics; Genome; Gene; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003797012,0.000340894,0.0005714124,0.0001329566,0.0001323004,0.00001604218,0.0005434894,0.0006956289,0.0004986656],"category_scores_gemma":[0.00008585308,0.0003201694,0.0002246472,0.0001668284,0.0007648224,0.00008999621,0.0002774523,0.0004915696,0.001777398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001040434,"about_ca_system_score_gemma":0.00022623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000746026,"about_ca_topic_score_gemma":0.000007205046,"domain_scores_codex":[0.9977512,0.0003299664,0.0006101411,0.0005216071,0.00006787853,0.000719185],"domain_scores_gemma":[0.9984561,0.0002661046,0.0002251594,0.0007271152,0.0002224775,0.00010311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001617763,0.001167783,0.0004029461,0.00007360081,0.00002900418,0.00001669752,0.0006491,0.00001007283,0.9871082,0.0002058716,0.009908139,0.00026686],"study_design_scores_gemma":[0.002040636,0.0005809886,0.00005304535,0.000009720799,0.00008862431,0.00003842474,0.0006272638,0.000006028572,0.9077782,0.0005381089,0.0879157,0.0003232485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539722,0.009060541,0.0002184556,0.0001271557,0.001883611,0.0002199051,0.00006269188,0.0000989526,0.03435656],"genre_scores_gemma":[0.9859164,0.00008445062,0.0005209422,0.0001629738,0.00006946542,0.00000803432,0.00008872087,0.00004691298,0.01310213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07932994,"threshold_uncertainty_score":0.999925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02254330171169381,"score_gpt":0.2222956337966903,"score_spread":0.1997523320849965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}