{"id":"W2209349785","doi":"10.1016/j.cell.2015.11.009","title":"Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":606,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Institute of Allergy and Infectious Diseases; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute","keywords":"Biology; Genomics; Pathogenicity; Computational biology; Cell; Genetics; Genome; Gene; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005624885,0.0004300108,0.0006834662,0.0003377142,0.0003371655,0.001390783,0.000596249,0.0006421896,0.001841018],"category_scores_gemma":[0.0007020246,0.0002749533,0.0002462474,0.0001889626,0.0008812047,0.00117836,0.0007017386,0.001680999,0.0004737288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005043441,"about_ca_system_score_gemma":0.0004510505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003212258,"about_ca_topic_score_gemma":0.0006843787,"domain_scores_codex":[0.9996942,0.00003961262,0.00001142275,0.00009172597,0.00009795077,0.00006505325],"domain_scores_gemma":[0.9995908,0.0001582672,0.00005685575,0.00007262536,0.00004861099,0.00007282553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001032761,0.00002261413,0.001297623,0.00004558733,0.000008707982,0.0001091749,0.0000498424,0.0008112394,0.9839008,0.004909473,0.0002685684,0.008473006],"study_design_scores_gemma":[0.00004686666,0.0004065222,0.01793842,0.00003532011,0.00007302672,0.000559978,0.000480365,0.03140102,0.910993,0.02524622,0.01275851,0.00006064968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9258214,0.003020776,0.06136899,0.001064649,0.0003378225,0.00004150155,0.0005507364,0.00082379,0.006970321],"genre_scores_gemma":[0.9877979,0.0009601719,0.009312184,0.0002519888,0.00008718756,0.00002297769,0.0001894356,0.0001694639,0.001208745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001841018,"threshold_uncertainty_score":0.006158769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02254330171169381,"score_gpt":0.2222956337966903,"score_spread":0.1997523320849965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}