{"id":"W2209848665","doi":"10.1126/scitranslmed.aac9816","title":"The 20 <i>S</i> proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection","year":2015,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; University of Calgary; Centre hospitalier universitaire de Québec; Institute for Research in Immunology and Cancer; Université de Montréal; Canadian Natural Resources","funders":"Natural Sciences and Engineering Research Council of Canada; Université de Montréal; Fonds de Recherche du Québec - Santé; Kidney Foundation of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canadian Donation and Transplantation Research Program","keywords":"Proteasome; Exosome; Microvesicles; Autoantibody; Extracellular vesicles; Cell biology; Vesicle; Apoptosis; Chemistry; Immunology; Medicine; Biology; microRNA; Antibody; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002487015,0.0003363079,0.0002499843,0.0002770752,0.0001125095,0.000447531,0.0001166086,0.0002508709,0.0006360463],"category_scores_gemma":[0.0001491608,0.000121665,0.0002699271,0.0001094227,0.0002963518,0.0003123602,0.0002312265,0.0002908943,0.00024079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004109081,"about_ca_system_score_gemma":0.0001535798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001387656,"about_ca_topic_score_gemma":0.0002219875,"domain_scores_codex":[0.9998417,0.00002705751,0.00001481408,0.00004168683,0.00003525605,0.00003942199],"domain_scores_gemma":[0.9998655,0.00001655926,0.00005572247,0.00001121024,0.0000126925,0.00003833546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006489854,0.00001035166,0.000281373,0.00001510119,0.000005729251,0.00003177748,0.000005501933,0.00002729834,0.9989265,0.00007665902,0.00001241721,0.0005424378],"study_design_scores_gemma":[0.000007731111,0.0001708322,0.00735656,0.00000454077,0.0000114593,0.000258218,0.00001618877,0.0006650838,0.9906749,0.0001007885,0.0007307732,0.000002953822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936424,0.001580016,0.00390604,0.00005059419,0.00002405816,0.00001377124,0.00009370947,0.00004336718,0.0006460905],"genre_scores_gemma":[0.9973634,0.0004606315,0.001247544,0.00003082018,0.00001074642,0.000007539697,0.0001228414,0.00001662367,0.000739928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006360463,"threshold_uncertainty_score":0.002981424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03642759343417261,"score_gpt":0.3017702875183412,"score_spread":0.2653426940841686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}