{"id":"W2210184605","doi":"10.1186/s12885-015-1957-7","title":"A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients","year":2015,"lang":"en","type":"review","venue":"BMC Cancer","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Deutsche Krebshilfe; Norges Forskningsråd; Stockholms Läns Landsting; Karolinska Institutet; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Breast Cancer Campaign; Cancerfonden; Agency for Science, Technology and Research; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; National Cancer Institute; Kuopion Yliopistollinen Sairaala; Francis Crick Institute; Deutsches Krebsforschungszentrum; Academy of Finland; Génome Québec; McGill University; Breast Cancer Research Foundation; University of Cambridge; Dietmar Hopp Stiftung; KWF Kankerbestrijding; Cancer Research UK; Kreftforeningen; Helsingin ja Uudenmaan Sairaanhoitopiiri; Ovarian Cancer Research Fund; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Itä-Suomen Yliopisto; European Commission; Susan G. Komen for the Cure","keywords":"Medicine; Breast cancer; Hazard ratio; Oncology; Single-nucleotide polymorphism; Chemotherapy; Internal medicine; Anthracycline; Radiation therapy; Cancer; Genotype; Biology; Genetics; Gene; Confidence interval","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004114147,0.0002330778,0.0002978505,0.000270613,0.0002364282,0.0003789735,0.0002149916,0.0004151764,0.001852061],"category_scores_gemma":[0.001490039,0.0001670411,0.0004624563,0.0004948041,0.000174877,0.0001306569,0.0001949495,0.0003068358,0.0001674811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001226534,"about_ca_system_score_gemma":0.000133012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001623435,"about_ca_topic_score_gemma":0.00175281,"domain_scores_codex":[0.9996935,0.00008304934,0.0000357973,0.0001197513,0.0000347397,0.00003314576],"domain_scores_gemma":[0.999334,0.0001901959,0.0002894345,0.00007877302,0.00004257213,0.00006494026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008974235,0.00002467882,0.9943309,0.0000202308,0.0003028987,0.0002212941,0.00008268045,0.00004521415,0.002132429,0.00002171858,0.0001178198,0.001802546],"study_design_scores_gemma":[0.00004032738,0.0001125898,0.9985074,0.000007130461,0.0002107013,0.0004691787,0.00006775517,0.0001210279,0.0002335329,0.00005511121,0.000171852,0.000003347604],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9992842,0.0003457195,0.00005077375,0.00003240415,0.000005198999,0.000002014411,0.0001543326,0.000001852367,0.0001233683],"genre_scores_gemma":[0.9997123,0.00005448902,0.00002617647,0.00001570983,0.000005726709,0.000002142831,0.0001023824,0.000001234537,0.00007987025],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001852061,"threshold_uncertainty_score":0.006195784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04493242607375915,"score_gpt":0.3381285997560995,"score_spread":0.2931961736823404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}