{"id":"W2210253930","doi":"10.1126/scisignal.aaa8695","title":"SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth","year":2015,"lang":"en","type":"article","venue":"Science Signaling","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Eye Institute; Fonds de Recherche du Québec - Santé; Deutsche Forschungsgemeinschaft; Deutsche Ophthalmologische Gesellschaft; Alcon Research Institute; BrightFocus Foundation; Foundation Fighting Blindness; Canadian Child Health Clinician Scientist Program; Seventh Framework Programme; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Boston Children's Hospital; Burroughs Wellcome Fund","keywords":"Retina; Retinal; Cell biology; SOCS3; Signal transduction; Pathological; Biology; Vascular endothelial growth factor; Angiogenesis; Cancer research; Macular degeneration; Muller glia; Neuroscience; VEGF receptors; Pathology; Progenitor cell; Medicine; STAT3; Stem cell; Ophthalmology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001902271,0.0001832055,0.0002640451,0.0002755201,0.0002426757,0.00008498528,0.0004485869,0.0001196762,0.0001128454],"category_scores_gemma":[0.0007349636,0.0001536441,0.00006117487,0.0004316559,0.0006631044,0.0002103091,0.0003176464,0.0003246867,0.0001344861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006292716,"about_ca_system_score_gemma":0.0002303573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007539761,"about_ca_topic_score_gemma":0.000004238133,"domain_scores_codex":[0.9980128,0.0003789802,0.0003125538,0.000543533,0.0001315296,0.0006206138],"domain_scores_gemma":[0.9993353,0.0001579748,0.00006171315,0.000204341,0.0001430351,0.00009760349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002109038,0.0000824952,0.0003909768,0.000007297884,0.000006138794,0.00003548302,0.001776593,0.0001506476,0.9965163,0.0002242657,0.0001195721,0.0004793266],"study_design_scores_gemma":[0.0005219951,0.0005652619,0.000776378,0.00007512515,0.00001226332,0.00009578079,0.001200955,0.00002618022,0.9952611,0.0002753228,0.0009791348,0.0002105516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971986,0.001002422,0.0003439827,0.0002916126,0.000627158,0.0002265864,0.000005258487,0.00004405954,0.0002603285],"genre_scores_gemma":[0.9989048,0.00001548984,0.0005536191,0.0002619218,0.00003404475,0.00001462286,0.000002802961,0.00001011906,0.0002026103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001706178,"threshold_uncertainty_score":0.6265425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269716740243169,"score_gpt":0.2623236105582277,"score_spread":0.239626443155796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}