{"id":"W2210253930","doi":"10.1126/scisignal.aaa8695","title":"SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth","year":2015,"lang":"en","type":"article","venue":"Science Signaling","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Eye Institute; Fonds de Recherche du Québec - Santé; Deutsche Forschungsgemeinschaft; Deutsche Ophthalmologische Gesellschaft; Alcon Research Institute; BrightFocus Foundation; Foundation Fighting Blindness; Canadian Child Health Clinician Scientist Program; Seventh Framework Programme; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Boston Children's Hospital; Burroughs Wellcome Fund","keywords":"Retina; Retinal; Cell biology; SOCS3; Signal transduction; Pathological; Biology; Vascular endothelial growth factor; Angiogenesis; Cancer research; Macular degeneration; Muller glia; Neuroscience; VEGF receptors; Pathology; Progenitor cell; Medicine; STAT3; Stem cell; Ophthalmology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001970692,0.0003879476,0.0003031826,0.0002354481,0.0001774217,0.0002837145,0.0001671425,0.0002904041,0.001090901],"category_scores_gemma":[0.0001377666,0.0001256025,0.0003600142,0.0001232865,0.0004115826,0.0001732743,0.0001965236,0.0006761933,0.0002589616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004545015,"about_ca_system_score_gemma":0.0006054943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001265852,"about_ca_topic_score_gemma":0.002488301,"domain_scores_codex":[0.9997571,0.00003293574,0.00003077986,0.00003519022,0.00005826283,0.00008573388],"domain_scores_gemma":[0.9998659,0.000009633719,0.00004627812,0.00001571268,0.00002091527,0.00004160773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001974264,0.00002690948,0.0002482652,0.00008892616,0.00001053167,0.00003316014,0.00001533253,0.00009807912,0.9966043,0.0002489431,0.0001571038,0.002270995],"study_design_scores_gemma":[0.0001250348,0.0007587036,0.007878166,0.00002597281,0.00006103731,0.0003938964,0.00008464887,0.002378542,0.981128,0.0002489867,0.006903152,0.00001391799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878232,0.003860022,0.004578481,0.0003611331,0.0001848822,0.00004327402,0.0006033425,0.0002640148,0.002281573],"genre_scores_gemma":[0.9960269,0.0007764047,0.001280973,0.000165308,0.00001765726,0.00004164926,0.0002688967,0.00002062411,0.001401534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265852,"threshold_uncertainty_score":0.003649473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02269716740243169,"score_gpt":0.2623236105582277,"score_spread":0.239626443155796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}