{"id":"W2210424010","doi":"10.1139/bcb-2015-0115","title":"Human acetyl-CoA:glucosamine-6-phosphate <i>N</i>-acetyltransferase 1 has a relaxed donor specificity and transfers acyl groups up to four carbons in length","year":2015,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; China Scholarship Council","keywords":"Glucosamine; Enzyme; Chemistry; Acetyl-CoA; Biochemistry; Biosynthesis; Coenzyme A; Phosphate; Mutant; Acetyltransferase; Cofactor; Stereochemistry; Acetylation; Reductase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000218241,0.0006302515,0.0004046637,0.0001850782,0.0001603249,0.0003750564,0.000402915,0.0004496646,0.001291696],"category_scores_gemma":[0.0002957357,0.0002427607,0.0002786169,0.0003948475,0.0004385018,0.0001947014,0.0002095362,0.0003930177,0.0009604901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004288815,"about_ca_system_score_gemma":0.0002103768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001712136,"about_ca_topic_score_gemma":0.001994306,"domain_scores_codex":[0.9996281,0.00006685561,0.00002372776,0.0001246626,0.00009769605,0.00005900533],"domain_scores_gemma":[0.99977,0.00004336476,0.0000646332,0.00004067391,0.00003693737,0.00004441879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001531323,0.0000301179,0.0008732899,0.00006565882,0.00001143916,0.00003903162,0.00001602139,0.00006748133,0.9957177,0.00007505297,0.00008837525,0.002862774],"study_design_scores_gemma":[0.00001111581,0.0002278917,0.005035548,0.000005915212,0.0000161314,0.0004966853,0.00001359816,0.0004718859,0.9876634,0.00003589867,0.006013525,0.000008383855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754954,0.005857162,0.01424413,0.0002074828,0.00006318279,0.00008879402,0.001412091,0.0003005436,0.002331202],"genre_scores_gemma":[0.9702865,0.002380243,0.01541484,0.000127937,0.00001867858,0.00007057502,0.005059572,0.00006528635,0.006576503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001712136,"threshold_uncertainty_score":0.004321158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02718992607451068,"score_gpt":0.2374105329940986,"score_spread":0.2102206069195879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}