{"id":"W2210776609","doi":"10.1021/jacs.5b07765","title":"Large-Scale Conformational Dynamics Control H5N1 Influenza Polymerase PB2 Binding to Importin α","year":2015,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Fondation Innovations en Infectiologie; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agence Nationale de la Recherche; European Molecular Biology Organization","keywords":"Chemistry; Importin; Small-angle X-ray scattering; Förster resonance energy transfer; Conformational change; Crystallography; Salt bridge; Single-molecule FRET; Molecular dynamics; Biophysics; Nuclear transport; Stereochemistry; Scattering; Cytoplasm; Biochemistry; Computational chemistry; Physics; Quantum mechanics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001246846,0.0001557365,0.0001771217,0.00005797876,0.0001538928,0.0003095548,0.0001790406,0.0001258723,0.0005215702],"category_scores_gemma":[0.0002824719,0.0001345205,0.0001137514,0.00007374104,0.0002526992,0.0002205153,0.0001971863,0.0003004175,0.0001587759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003682291,"about_ca_system_score_gemma":0.000120727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089727,"about_ca_topic_score_gemma":0.0009578554,"domain_scores_codex":[0.9999229,0.000007748613,0.000003428681,0.00002892176,0.00001913866,0.00001779337],"domain_scores_gemma":[0.9999096,0.00001983636,0.00001721302,0.00001004234,0.00001340543,0.00002991566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002988323,0.00005407005,0.002414927,0.00002504327,0.00002067659,0.00006801445,0.0001237746,0.001702228,0.9934095,0.0002047184,0.00008204499,0.001596233],"study_design_scores_gemma":[0.0000461571,0.0004140217,0.05185318,0.00001222728,0.00002853613,0.0001674227,0.000305945,0.09244449,0.8528616,0.0002984297,0.001534434,0.00003351573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991634,0.00004451342,0.0005006202,0.00001013533,0.000002390487,0.000003120508,0.00002920587,0.00001531644,0.0002312701],"genre_scores_gemma":[0.9993436,0.00004477373,0.0002772208,0.000008296743,0.000001537656,0.000005351224,0.00008814037,0.000009251026,0.0002218557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001089727,"threshold_uncertainty_score":0.002671659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00599145767385261,"score_gpt":0.2577849837899954,"score_spread":0.2517935261161428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}