{"id":"W2210776609","doi":"10.1021/jacs.5b07765","title":"Large-Scale Conformational Dynamics Control H5N1 Influenza Polymerase PB2 Binding to Importin α","year":2015,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Fondation Innovations en Infectiologie; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Agence Nationale de la Recherche; European Molecular Biology Organization","keywords":"Chemistry; Importin; Small-angle X-ray scattering; Förster resonance energy transfer; Conformational change; Crystallography; Salt bridge; Single-molecule FRET; Molecular dynamics; Biophysics; Nuclear transport; Stereochemistry; Scattering; Cytoplasm; Biochemistry; Computational chemistry; Physics; Quantum mechanics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003545732,0.000135031,0.0002452523,0.00001455233,0.00006328964,0.00002613577,0.0003832953,0.00008250577,0.000003804421],"category_scores_gemma":[0.0001927645,0.00009351456,0.000357799,0.0001681585,0.0001486231,0.000009772455,0.000160691,0.0002441069,0.000002406252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001155266,"about_ca_system_score_gemma":0.000213394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000972752,"about_ca_topic_score_gemma":0.000003439264,"domain_scores_codex":[0.9988694,0.00003402149,0.0004104834,0.0001180297,0.0003145323,0.0002535789],"domain_scores_gemma":[0.9987081,0.0000166639,0.0006190318,0.0002091572,0.0002044093,0.0002426327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003177745,0.0000564917,0.0135102,0.000006701911,0.0001742727,0.00000131133,0.0004530593,0.0004404946,0.9711942,0.00004473326,0.01295249,0.0008482416],"study_design_scores_gemma":[0.008339373,0.001164007,0.006840434,0.00007891973,0.0002951725,0.0006737505,0.008842821,0.01032942,0.8962479,0.00096516,0.06506765,0.001155455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989665,0.00009228479,0.008518493,0.001299906,0.0001363386,0.00009552631,0.00007887279,0.000004656579,0.0001088959],"genre_scores_gemma":[0.988023,0.000009010544,0.004084443,0.007407395,0.0003925911,0.000002831145,0.00001615594,0.0000143804,0.00005013222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07494638,"threshold_uncertainty_score":0.3813413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00599145767385261,"score_gpt":0.2577849837899954,"score_spread":0.2517935261161428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}