{"id":"W2210966880","doi":"10.1097/dss.0000000000000578","title":"REFINE-1, a Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial With ATX-101, an Injectable Drug for Submental Fat Reduction","year":2015,"lang":"en","type":"article","venue":"Dermatologic Surgery","topic":"Facial Rejuvenation and Surgery Techniques","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Placebo; Adverse effect; Randomized controlled trial; Internal medicine; Magnetic resonance imaging; Clinical trial; Phases of clinical research; Gastroenterology; Surgery; Pathology; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002794174,0.0003744145,0.00197529,0.0005261387,0.0001563461,0.00006617579,0.0001008471,0.0002204203,0.00006904702],"category_scores_gemma":[0.001172501,0.0002571391,0.0005533163,0.0003175163,0.0002101625,0.0004276591,0.00002678921,0.0002246682,0.00001672297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001686411,"about_ca_system_score_gemma":0.0003528266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009591803,"about_ca_topic_score_gemma":0.00001815836,"domain_scores_codex":[0.9969315,0.0004734,0.001042706,0.000504713,0.0005266783,0.0005210359],"domain_scores_gemma":[0.9972672,0.00105899,0.0004608358,0.0003799066,0.0004238991,0.0004091174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9509792,0.001449078,0.0003739357,0.00003780806,0.0002066029,0.00009777751,0.0002843319,0.000004306567,0.0001739198,0.000184543,0.04434143,0.00186711],"study_design_scores_gemma":[0.9687216,0.000354111,0.000001176066,0.00007942995,0.0002515245,0.000449074,0.0006364577,0.001174773,0.008911776,0.0001305385,0.018972,0.000317525],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824882,0.0003656495,0.001422369,0.003389883,0.001391389,0.008352525,0.00001954916,0.0005907122,0.001979706],"genre_scores_gemma":[0.9918924,0.00007151567,0.001218395,0.001135115,0.0002191099,0.003843876,0.0005523023,0.00004851952,0.001018752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02536943,"threshold_uncertainty_score":0.9999881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08670669487855001,"score_gpt":0.3530769048483154,"score_spread":0.2663702099697655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}