{"id":"W2210966880","doi":"10.1097/dss.0000000000000578","title":"REFINE-1, a Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial With ATX-101, an Injectable Drug for Submental Fat Reduction","year":2015,"lang":"en","type":"article","venue":"Dermatologic Surgery","topic":"Facial Rejuvenation and Surgery Techniques","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Placebo; Adverse effect; Randomized controlled trial; Internal medicine; Magnetic resonance imaging; Clinical trial; Phases of clinical research; Gastroenterology; Surgery; Pathology; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001409831,0.001406068,0.002087987,0.0005341127,0.0004494776,0.0009263536,0.001059685,0.001575561,0.007606654],"category_scores_gemma":[0.001314164,0.0005552076,0.001159066,0.0003787446,0.0009946565,0.000764763,0.0002830885,0.00235734,0.000972721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005304319,"about_ca_system_score_gemma":0.001111838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007491804,"about_ca_topic_score_gemma":0.002327878,"domain_scores_codex":[0.9995481,0.0002088566,0.0000232039,0.00008552898,0.00006315912,0.000071034],"domain_scores_gemma":[0.9993094,0.0001673458,0.000237676,0.00005292992,0.0000611881,0.0001714713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9340692,0.01330395,0.001266227,0.001336392,0.0007564134,0.00009436205,0.0001231736,0.0004995538,0.01602837,0.0002915328,0.002503301,0.02972759],"study_design_scores_gemma":[0.9405742,0.05562955,0.001750903,0.00002826074,0.0001811842,0.00005719905,0.00001546228,0.0003314155,0.0006354757,0.00008513479,0.0006984492,0.00001267028],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753905,0.006484748,0.001824833,0.0008086281,0.000423063,0.008578214,0.002347404,0.0005590125,0.003583676],"genre_scores_gemma":[0.9667904,0.004015922,0.005386908,0.002130126,0.000507408,0.01237196,0.002669354,0.00008897456,0.006039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007606654,"threshold_uncertainty_score":0.02544677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08670669487855001,"score_gpt":0.3530769048483154,"score_spread":0.2663702099697655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}