{"id":"W2211196883","doi":"10.1007/s11239-015-1264-9","title":"PON1 Q192R genetic variant and response to clopidogrel and prasugrel: pharmacokinetics, pharmacodynamics, and a meta-analysis of clinical outcomes","year":2015,"lang":"en","type":"review","venue":"Journal of Thrombosis and Thrombolysis","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"","keywords":"Prasugrel; Clopidogrel; Medicine; Internal medicine; Thienopyridine; Pharmacodynamics; Myocardial infarction; Aspirin; Cardiology; Pharmacology; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004250423,0.0007298386,0.01362157,0.001166541,0.00009421913,0.00009080811,0.0002117831,0.0003726392,0.0001183932],"category_scores_gemma":[0.0003946735,0.0004649602,0.005031528,0.0008263781,0.0004308384,0.0001286168,0.0002542927,0.0005980935,0.000001242793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004398025,"about_ca_system_score_gemma":0.0003451961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002981438,"about_ca_topic_score_gemma":0.000004898079,"domain_scores_codex":[0.9940948,0.001345464,0.002680987,0.0006936091,0.0008568516,0.0003282816],"domain_scores_gemma":[0.9952884,0.0009269163,0.001762156,0.0005336452,0.0005129423,0.0009758876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.000619743,0.0004655926,0.003587984,0.002868718,0.80491,0.0002461581,0.000303686,0.00001015718,0.00002289463,0.00001181431,0.0003662773,0.1865869],"study_design_scores_gemma":[0.002081698,0.0007509951,0.04273084,0.0003573018,0.8639541,0.0004690022,0.00009990568,0.00007776371,0.000001723655,0.00002207338,0.08903833,0.0004162453],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1039251,0.8943961,0.0001482843,0.0004910369,0.0001449327,0.0006030408,0.0002683711,0.00001064067,0.0000125275],"genre_scores_gemma":[0.01608784,0.9810601,0.002197333,0.0003562843,0.0001470123,0.00001300633,0.00001476005,0.00007313667,0.00005051477],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1861707,"threshold_uncertainty_score":0.9997802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2049930932032296,"score_gpt":0.4756738696671398,"score_spread":0.2706807764639101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}