{"id":"W2211196883","doi":"10.1007/s11239-015-1264-9","title":"PON1 Q192R genetic variant and response to clopidogrel and prasugrel: pharmacokinetics, pharmacodynamics, and a meta-analysis of clinical outcomes","year":2015,"lang":"en","type":"review","venue":"Journal of Thrombosis and Thrombolysis","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"","keywords":"Prasugrel; Clopidogrel; Medicine; Internal medicine; Thienopyridine; Pharmacodynamics; Myocardial infarction; Aspirin; Cardiology; Pharmacology; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00332052,0.001601901,0.006119256,0.001105504,0.0003104924,0.00125237,0.001269806,0.001378912,0.00202622],"category_scores_gemma":[0.006254232,0.0007787354,0.01814296,0.002076033,0.0002965135,0.0006814941,0.0007570484,0.001779427,0.0001902959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005840323,"about_ca_system_score_gemma":0.0008311903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003410624,"about_ca_topic_score_gemma":0.006076287,"domain_scores_codex":[0.9981445,0.0008483676,0.0003651863,0.0003387496,0.0001850368,0.0001181607],"domain_scores_gemma":[0.9968284,0.002282434,0.0004406407,0.0001935724,0.0001849527,0.00007002922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.01114117,0.0001313927,0.03897239,0.03883805,0.8739386,0.0002974143,0.00008993803,0.001079214,0.0007290663,0.0002450801,0.001243795,0.03329388],"study_design_scores_gemma":[0.001070506,0.0005151851,0.03282662,0.001521069,0.9598368,0.0002379863,0.0000619872,0.0006313706,0.0002212914,0.0005305073,0.002507186,0.00003945053],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04444056,0.953355,0.0008212575,0.0003204156,0.0002258991,0.00004414538,0.0004270195,0.000025226,0.0003405387],"genre_scores_gemma":[0.6007417,0.3931542,0.002562163,0.0008922809,0.0005382254,0.0001479609,0.001190108,0.00003378598,0.0007395053],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006119256,"threshold_uncertainty_score":0.01756078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2049930932032296,"score_gpt":0.4756738696671398,"score_spread":0.2706807764639101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}