{"id":"W2211198877","doi":"10.1021/acs.oprd.5b00141","title":"Application of Continuous Preferential Crystallization to Efficiently Access Enantiopure Chemicals","year":2015,"lang":"en","type":"article","venue":"Organic Process Research & Development","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Division of Chemistry; National Science Foundation","keywords":"Crystallization; Enantiopure drug; Process (computing); Fractional crystallization (geology); Process engineering; Throughput; Batch processing; Computer science; Chemical engineering; Chemistry; Engineering; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000534061,0.0005574325,0.0003950259,0.0004583837,0.000311387,0.0007793694,0.0005630914,0.0004738609,0.002209026],"category_scores_gemma":[0.0004929613,0.0003693086,0.0004304321,0.0005108399,0.0005641198,0.000694504,0.0007776272,0.001020986,0.001234469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005126208,"about_ca_system_score_gemma":0.0004407573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006641517,"about_ca_topic_score_gemma":0.001494678,"domain_scores_codex":[0.9996626,0.00003298833,0.0000209641,0.0001156016,0.000126791,0.00004102344],"domain_scores_gemma":[0.9996501,0.0001414667,0.00005374198,0.0000803209,0.00005666749,0.00001761449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005353026,0.00001907752,0.000151771,0.0003094631,0.00001797556,0.0001348123,0.000047513,0.0004167595,0.9794449,0.001441661,0.0007061787,0.01725641],"study_design_scores_gemma":[0.00001219556,0.00006166017,0.0003669244,0.0000109703,0.00001363173,0.000270558,0.00001475881,0.00198397,0.9861739,0.000211426,0.01086558,0.00001437126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.429048,0.02820668,0.5021344,0.000907018,0.0004291664,0.0004441264,0.00134486,0.003602814,0.03388298],"genre_scores_gemma":[0.733306,0.01703347,0.2359255,0.0004204795,0.000132696,0.0003151385,0.001119818,0.0004430996,0.01130382],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002209026,"threshold_uncertainty_score":0.007389963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04791799624164302,"score_gpt":0.3752575243545946,"score_spread":0.3273395281129516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}