{"id":"W2211214375","doi":"10.1200/jco.2014.32.18_suppl.lba9000","title":"Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL).","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Cohort; Ipilimumab; Gastroenterology; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001849957,0.0005982025,0.001132797,0.0004647665,0.0002960042,0.0006510033,0.0003854664,0.0005446995,0.0009835908],"category_scores_gemma":[0.000969007,0.0005134548,0.001588025,0.0006751557,0.0003826649,0.0003508324,0.0004546501,0.0006164124,0.0002942519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001074811,"about_ca_system_score_gemma":0.0007612435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092821,"about_ca_topic_score_gemma":0.002149008,"domain_scores_codex":[0.9994393,0.0002133131,0.00005753281,0.000129022,0.00009880374,0.00006200233],"domain_scores_gemma":[0.9995408,0.0001048561,0.0001993877,0.00003261732,0.00002541063,0.00009702155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2611579,0.003527038,0.6184239,0.0011103,0.008218682,0.0005779627,0.000375041,0.003039217,0.02237464,0.0001226413,0.002078931,0.07899366],"study_design_scores_gemma":[0.0289565,0.09825937,0.8532086,0.00009496186,0.007994635,0.001235516,0.0001406535,0.001988439,0.003558193,0.0001585856,0.004352045,0.00005242477],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974486,0.001426917,0.0001054935,0.00004118232,0.000007245696,0.0001338341,0.0005586093,0.000009998947,0.0002681266],"genre_scores_gemma":[0.9983433,0.0004079913,0.0001660754,0.00006369222,0.00002275486,0.0001033483,0.0007111638,0.000003272115,0.0001783955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001849957,"threshold_uncertainty_score":0.009783685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06520723822404939,"score_gpt":0.4496459923851462,"score_spread":0.3844387541610968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}