{"id":"W2211243458","doi":"10.1128/jvi.02642-15","title":"Membrane Perturbation-Associated Ca <sup>2+</sup> Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; IRF3; Sendai virus; Virus; Viral entry; Cell biology; Interferon; Virology; Viral envelope; Viral replication; Signal transduction; DNA virus; Innate immune system; Receptor; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00232385,0.0001802807,0.0004568028,0.0001348284,0.0002885346,0.00003606256,0.0002111318,0.0002493236,0.00006199376],"category_scores_gemma":[0.003760465,0.0001299268,0.0001128498,0.0001157474,0.000169022,0.000102486,0.0001018663,0.0003436717,0.00004422611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001371051,"about_ca_system_score_gemma":0.0001966276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003300715,"about_ca_topic_score_gemma":0.0000157526,"domain_scores_codex":[0.9976825,0.001054499,0.0006197977,0.0001752728,0.00006377274,0.0004041932],"domain_scores_gemma":[0.996842,0.002119035,0.0004319537,0.0001708621,0.0003609221,0.00007517101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01985099,0.00007045763,0.0001045434,0.000006227542,0.0003424078,0.00002819229,0.006441883,0.0006575916,0.9715071,0.00001283985,0.0005236134,0.0004541634],"study_design_scores_gemma":[0.02056613,0.00715714,0.03314056,0.0003359345,0.0006512622,0.003072881,0.02120394,0.006101612,0.8516877,0.0002096005,0.05498374,0.0008894456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899344,0.002043843,0.001670702,0.005644858,0.0004058904,0.0002339661,0.00004325502,0.0000116743,0.00001137128],"genre_scores_gemma":[0.996508,0.0000659729,0.000271911,0.001792083,0.00008178247,0.000004520097,0.000005343886,0.00002259752,0.001247799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1198193,"threshold_uncertainty_score":0.529826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736186760188368,"score_gpt":0.2667205993448285,"score_spread":0.2293587317429448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}