{"id":"W2211243458","doi":"10.1128/jvi.02642-15","title":"Membrane Perturbation-Associated Ca <sup>2+</sup> Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; IRF3; Sendai virus; Virus; Viral entry; Cell biology; Interferon; Virology; Viral envelope; Viral replication; Signal transduction; DNA virus; Innate immune system; Receptor; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001575756,0.0003984157,0.0004190801,0.0001298268,0.0002347474,0.0006188762,0.0002965344,0.0005706914,0.001891433],"category_scores_gemma":[0.0002729943,0.0001704856,0.0002782625,0.0001133848,0.000401092,0.0003922362,0.0003097644,0.0005701358,0.0006863935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006353193,"about_ca_system_score_gemma":0.0004198314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005748215,"about_ca_topic_score_gemma":0.0007196033,"domain_scores_codex":[0.9997386,0.0000262597,0.00002948088,0.00006081668,0.00006679526,0.00007805226],"domain_scores_gemma":[0.9997123,0.00005030618,0.0001092608,0.00003449118,0.00003587658,0.00005775503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002224045,0.00001635823,0.0004154681,0.00003400372,0.000002455107,0.0000542114,0.000006166232,0.00004757994,0.9986249,0.0000544569,0.00002168242,0.0005003262],"study_design_scores_gemma":[0.00004056804,0.000242843,0.02934105,0.00001162689,0.00001290514,0.0005847256,0.00007114577,0.001641177,0.9661175,0.0001592935,0.001768867,0.000008381034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932311,0.002111071,0.002354676,0.0002245717,0.00004019381,0.0000340339,0.0005070656,0.00009850579,0.00139886],"genre_scores_gemma":[0.9965414,0.000305939,0.001554975,0.00006676885,0.00001738774,0.00004353649,0.0005649779,0.00001375828,0.0008911572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001891433,"threshold_uncertainty_score":0.00632745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736186760188368,"score_gpt":0.2667205993448285,"score_spread":0.2293587317429448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}