{"id":"W2211406503","doi":"10.1038/nn.4190","title":"An epigenetic gateway to brain tumor cell identity","year":2015,"lang":"en","type":"review","venue":"Nature Neuroscience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Epigenetics; Epigenome; Biology; Chromatin; DNA methylation; Neuroscience; Cancer; Phenotype; Histone; Brain tumor; Genetics; Gene; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007316956,0.0004109836,0.0005665286,0.0001629226,0.0001265809,0.0001699766,0.001243404,0.0006032769,0.00000571386],"category_scores_gemma":[0.0005593918,0.000360255,0.0002069216,0.0006480925,0.0000925503,0.00001318638,0.0002938325,0.0005588533,0.00004465931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003679197,"about_ca_system_score_gemma":0.000498314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000522246,"about_ca_topic_score_gemma":0.00002074097,"domain_scores_codex":[0.9971554,0.0003042532,0.0003851138,0.001190952,0.0005281404,0.0004360939],"domain_scores_gemma":[0.9981084,0.00002356464,0.0002373082,0.001010008,0.0001737299,0.0004469327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000222151,0.0003983743,0.00005251142,0.002933304,0.00001154718,0.00007448449,0.00005225561,0.0002730254,0.4018674,0.0001156974,0.007953236,0.586246],"study_design_scores_gemma":[0.00007283971,0.0004490227,0.00004043595,0.0001477189,0.00004495577,0.00001035034,0.000002022725,0.000008951162,0.009337957,0.00006006597,0.9894236,0.0004021357],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001457867,0.9947628,0.001104173,0.00003295181,0.001374538,0.0006455386,0.00008331395,0.00002173241,0.0005170262],"genre_scores_gemma":[0.002930013,0.9936282,0.0006013392,0.001184931,0.0005458564,0.00004922057,0.0001421594,0.00007510439,0.0008431819],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9814703,"threshold_uncertainty_score":0.999885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02919835851698676,"score_gpt":0.3829774546371193,"score_spread":0.3537790961201325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}