{"id":"W2211406503","doi":"10.1038/nn.4190","title":"An epigenetic gateway to brain tumor cell identity","year":2015,"lang":"en","type":"review","venue":"Nature Neuroscience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research","keywords":"Epigenetics; Epigenome; Biology; Chromatin; DNA methylation; Neuroscience; Cancer; Phenotype; Histone; Brain tumor; Genetics; Gene; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006274948,0.0007785358,0.001064905,0.0009390389,0.0002722737,0.001064662,0.0009307851,0.001601285,0.001933245],"category_scores_gemma":[0.0006471558,0.0002760623,0.0002370085,0.0009672826,0.001097545,0.001463328,0.0009733273,0.002206401,0.0008862376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008723389,"about_ca_system_score_gemma":0.001018868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009355248,"about_ca_topic_score_gemma":0.002594155,"domain_scores_codex":[0.9998842,0.00001893696,0.00001683816,0.00002757762,0.0000365812,0.00001576738],"domain_scores_gemma":[0.9998197,0.00008278414,0.00002693073,0.000008074149,0.00003880392,0.00002365063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001093859,0.00003879217,0.0002797,0.007254551,0.00007433198,0.0005764635,0.0000777305,0.0007066072,0.006703767,0.02317657,0.05217267,0.9088294],"study_design_scores_gemma":[0.00001268504,0.00002666114,0.0005998244,0.001036083,0.00006392978,0.001014832,0.00005766351,0.0001524883,0.001655803,0.00723189,0.9881294,0.0000186981],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001545067,0.9969313,0.0004670482,0.0008552573,0.0004826058,0.000002650589,0.00001945688,0.000009644529,0.001077425],"genre_scores_gemma":[0.001568552,0.9962422,0.0002735273,0.0004539251,0.0004900337,0.000004684785,0.00002736203,0.000001905179,0.0009378899],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001933245,"threshold_uncertainty_score":0.006467342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02919835851698676,"score_gpt":0.3829774546371193,"score_spread":0.3537790961201325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}