{"id":"W2211969541","doi":"10.1021/acs.langmuir.5b03777","title":"Tuning Toehold Length and Temperature to Achieve Rapid, Colorimetric Detection of DNA from the Disassembly of DNA–Gold Nanoparticle Aggregates","year":2015,"lang":"en","type":"article","venue":"Langmuir","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Grand Challenges Canada; Alfred P. Sloan Foundation","keywords":"Colloidal gold; DNA; Nanotechnology; Chemistry; Limiting; Nanoparticle; Biophysics; Materials science; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004243804,0.0004934476,0.0002483681,0.0001975876,0.0001715015,0.00034433,0.0003658407,0.0003815695,0.0005728984],"category_scores_gemma":[0.0006168678,0.0002706112,0.0001720396,0.0001671378,0.0002727118,0.0004440846,0.0002640852,0.0007469925,0.0003502688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002423793,"about_ca_system_score_gemma":0.0002096103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002342017,"about_ca_topic_score_gemma":0.0007907139,"domain_scores_codex":[0.999668,0.00004302676,0.00004137969,0.0000933093,0.0001111101,0.00004325258],"domain_scores_gemma":[0.9995672,0.0001541136,0.0001355613,0.00004809257,0.00005500794,0.00003997156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001465791,0.00000953485,0.00002551992,0.00002250763,0.000001518589,0.00001014848,0.00001160723,0.00006271755,0.9992043,0.00003143722,0.00001042533,0.0005955813],"study_design_scores_gemma":[0.000001880847,0.00002878226,0.0001464037,0.000001190737,0.000001521538,0.00001982417,0.000002501756,0.0003777554,0.9991612,0.000007625645,0.0002481913,0.000003057036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9466382,0.002304434,0.04865157,0.0001438111,0.00006930667,0.00009996622,0.0001354753,0.0004278047,0.001529433],"genre_scores_gemma":[0.9574551,0.001047698,0.03892121,0.0001563128,0.00001758819,0.00007794653,0.0001665414,0.00009036396,0.002067254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005728984,"threshold_uncertainty_score":0.002244413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01413963644147577,"score_gpt":0.2489411391641555,"score_spread":0.2348015027226797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}