{"id":"W2212030004","doi":"10.1016/j.immuni.2015.11.010","title":"Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation","year":2015,"lang":"en","type":"article","venue":"Immunity","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":225,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; St. Michael's Hospital; Centre Hospitalier de l’Université de Montréal; McGill University; Montreal Neurological Institute and Hospital; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Multiple Sclerosis Society; U.S. Public Health Service; Multiple Sclerosis Society of Canada","keywords":"Lymphotoxin; Meninges; Stromal cell; Lymphotoxin beta receptor; Biology; Neuroinflammation; Immune system; Cell biology; Immunology; Experimental autoimmune encephalomyelitis; Chemokine; Microglia; Multiple sclerosis; Pathology; Neuroscience; Cancer research; Inflammation; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002797897,0.0005243289,0.0002969223,0.0004423434,0.0004235108,0.0009390572,0.0001492755,0.000395244,0.002176049],"category_scores_gemma":[0.0002526262,0.0001690633,0.0003451214,0.0001594649,0.0003051501,0.0005916497,0.0006552343,0.001133883,0.0006242191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006288266,"about_ca_system_score_gemma":0.0007214538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000840675,"about_ca_topic_score_gemma":0.002146204,"domain_scores_codex":[0.9996446,0.00005890117,0.00002096672,0.00004437922,0.00007694948,0.0001540988],"domain_scores_gemma":[0.9997664,0.00001782481,0.00005782893,0.00001908025,0.0000428169,0.00009605329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003286522,0.0000512622,0.002629371,0.00005909005,0.00001640784,0.0008319613,0.0001314401,0.0001357534,0.9899367,0.0008821171,0.000167203,0.004829933],"study_design_scores_gemma":[0.00005046241,0.000583721,0.02725523,0.00006727793,0.00005833646,0.001406574,0.001252418,0.001861851,0.9587014,0.00099472,0.007752556,0.00001551537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850445,0.0027584,0.007067156,0.0003571971,0.0001400009,0.00005278791,0.0002690529,0.0001030293,0.004207816],"genre_scores_gemma":[0.9925801,0.000847965,0.003052027,0.0001092247,0.0000494769,0.00003063606,0.0001477012,0.00002177686,0.003161107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002176049,"threshold_uncertainty_score":0.007279575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09819671445659925,"score_gpt":0.2910296273211111,"score_spread":0.1928329128645118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}