{"id":"W2212055661","doi":"10.1124/mol.115.100792","title":"Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital","funders":"Deutsche Forschungsgemeinschaft","keywords":"TRPC6; TRPC; TRPC3; Transient receptor potential channel; Chemistry; Diacylglycerol kinase; Pharmacology; Biochemistry; Receptor; Biology; Protein kinase C; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119873,0.00008037692,0.0001102376,0.00008893417,0.00004116747,0.00001517353,0.00009461655,0.00005919042,0.00003815641],"category_scores_gemma":[0.0001071928,0.00007424761,0.00003180138,0.0001480091,0.0001027215,0.00008328751,0.00006334498,0.00007950898,0.00005303583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002097798,"about_ca_system_score_gemma":0.00004024867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001139524,"about_ca_topic_score_gemma":1.774429e-7,"domain_scores_codex":[0.9990585,0.0002105483,0.0001885917,0.0002354725,0.0001701038,0.0001367149],"domain_scores_gemma":[0.999634,0.00002565215,0.000116205,0.00005860336,0.00006993907,0.00009560219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003910645,0.00006102231,0.000006748987,0.00001037273,0.00000558024,0.00001849013,0.0003271166,0.0002693106,0.9969122,0.000309048,0.0009433674,0.001097605],"study_design_scores_gemma":[0.000756663,0.00009935381,0.000009791462,0.000002733841,0.00002592007,0.00002913147,0.0000444109,0.0009002362,0.9950072,0.0006213617,0.002429262,0.00007392373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957495,0.00008903215,0.0009862955,0.001271587,0.001206978,0.0002261023,0.000004552385,0.00002701704,0.0004388887],"genre_scores_gemma":[0.9988052,0.00004288797,0.0000364643,0.0005422052,0.00006295681,0.00001972602,0.000003631195,0.00001100496,0.0004759365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00305564,"threshold_uncertainty_score":0.302773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03321459213703334,"score_gpt":0.3195421162493506,"score_spread":0.2863275241123173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}