{"id":"W2212055661","doi":"10.1124/mol.115.100792","title":"Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital","funders":"Deutsche Forschungsgemeinschaft","keywords":"TRPC6; TRPC; TRPC3; Transient receptor potential channel; Chemistry; Diacylglycerol kinase; Pharmacology; Biochemistry; Receptor; Biology; Protein kinase C; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000609455,0.0006604239,0.0006845154,0.0005735095,0.0004185796,0.0004337359,0.0005893057,0.0005633821,0.00255559],"category_scores_gemma":[0.0003209582,0.000221518,0.0005641916,0.0003217928,0.0003382765,0.0003181842,0.0003685419,0.0009947162,0.0009925172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003319631,"about_ca_system_score_gemma":0.0006582246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008983638,"about_ca_topic_score_gemma":0.001647784,"domain_scores_codex":[0.9997942,0.00003716387,0.00001835216,0.00003854641,0.00004876042,0.00006301876],"domain_scores_gemma":[0.9998658,0.00001642916,0.0000184036,0.00001601426,0.00003997805,0.00004347994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001151249,0.0004433149,0.0003087174,0.0002338926,0.00005495015,0.0003117797,0.00004979411,0.0005665287,0.9814038,0.0003967896,0.0007655318,0.01431366],"study_design_scores_gemma":[0.000579278,0.003980864,0.001604295,0.00002997549,0.0001548615,0.0006661049,0.00003911119,0.001196449,0.9779277,0.0001055706,0.01368942,0.00002648554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9409947,0.01324241,0.02699495,0.001275125,0.0003975492,0.001407135,0.00255304,0.0007138682,0.01242129],"genre_scores_gemma":[0.958195,0.01192911,0.01596467,0.0005156653,0.00009645871,0.0003277232,0.003728954,0.00006691421,0.009175509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00255559,"threshold_uncertainty_score":0.008549273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03321459213703334,"score_gpt":0.3195421162493506,"score_spread":0.2863275241123173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}