{"id":"W2212855644","doi":"10.1124/mol.115.101980","title":"Biased Type 1 Cannabinoid Receptor Signaling Influences Neuronal Viability in a Cell Culture Model of Huntington Disease","year":2015,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Cannabinoid receptor; Cannabinoid; Endocannabinoid system; Cannabidiol; Biology; Agonist; Signal transduction; Viability assay; Medium spiny neuron; Receptor; Pharmacology; Cannabinoid receptor type 2; Cell biology; Neuroscience; Biochemistry; Cell; Basal ganglia; Psychology; Cannabis; Central nervous system; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000490402,0.0001859918,0.0003559043,0.0001929362,0.00003065366,0.00001023574,0.0001866642,0.0001171486,0.0001956681],"category_scores_gemma":[0.0002630704,0.0001678331,0.0001168877,0.000492875,0.0002065383,0.00005947139,0.0001085955,0.0004202981,0.0000134622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001512996,"about_ca_system_score_gemma":0.001327137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001464585,"about_ca_topic_score_gemma":0.000006073865,"domain_scores_codex":[0.9980851,0.0002448382,0.0003740321,0.0004074826,0.000463483,0.0004250427],"domain_scores_gemma":[0.9986323,0.000009857752,0.0001008903,0.0002227059,0.0005174359,0.0005167855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001383601,0.0005143554,0.009080592,0.0002337616,0.00002140217,0.00004441833,0.0003730837,0.01529315,0.9546735,0.00001699507,0.01822993,0.0001351539],"study_design_scores_gemma":[0.0042868,0.0007353236,0.002734918,0.00003379106,0.0001411186,0.000002311381,0.0001378767,0.02136452,0.9613937,0.0001859747,0.008727622,0.0002561074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946696,0.0004595506,0.00007402684,0.003465598,0.0001955056,0.0006181417,0.00002713783,0.00002858853,0.0004618393],"genre_scores_gemma":[0.996823,0.00001891784,0.0003111125,0.001547955,0.00007400702,0.00006983385,0.00003824128,0.00002669758,0.001090194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009502309,"threshold_uncertainty_score":0.6844037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03032617256808773,"score_gpt":0.3296348039892438,"score_spread":0.299308631421156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}