{"id":"W2212875100","doi":"10.1016/j.dadm.2015.11.008","title":"Prediction of Alzheimer's disease pathophysiology based on cortical thickness patterns","year":2015,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Norman Cousins Center for Psychoneuroimmunology; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Servier; National Institutes of Health; Asan Institute for Life Sciences, Asan Medical Center; Eisai; Ministry of Science, ICT and Future Planning; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Ministry of Trade, Industry and Energy; Synarc; F. Hoffmann-La Roche; Takeda Pharmaceutical Company; Genentech; Biogen Idec; Medpace; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Merck; Alzheimer's Association; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics","keywords":"Atrophy; Pathophysiology; Neuroimaging; Magnetic resonance imaging; Pathology; Positron emission tomography; Cerebrospinal fluid; Posterior cortical atrophy; Neuroscience; Alzheimer's Disease Neuroimaging Initiative; Medicine; Hippocampus; Disease; Alzheimer's disease; Amyloid (mycology); Psychology; Dementia; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007833163,0.0006647178,0.0002986624,0.002120307,0.0002507214,0.0005985684,0.0003021931,0.0003048536,0.00125335],"category_scores_gemma":[0.002660629,0.0001601005,0.0002678005,0.0005841845,0.000194014,0.0003542887,0.0003395696,0.0002239406,0.0004376032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001742357,"about_ca_system_score_gemma":0.0002029239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001656097,"about_ca_topic_score_gemma":0.001985848,"domain_scores_codex":[0.9998081,0.00005297007,0.00003491961,0.00003669497,0.00004534328,0.00002202562],"domain_scores_gemma":[0.9988066,0.0002241394,0.0004652788,0.0000759352,0.0002856125,0.0001424277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003528417,0.00003064657,0.9876124,0.0000229719,0.00008902868,0.000102431,0.0000444012,0.0004306556,0.002237517,0.00002126151,0.0001478158,0.008907968],"study_design_scores_gemma":[0.00001463961,0.0001231545,0.9946079,0.00001437009,0.00004519903,0.000677724,0.00008275673,0.002854443,0.001250844,0.000170732,0.0001518903,0.000006324882],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980489,0.0003138836,0.0008670949,0.00002558827,0.000004528705,0.00002387931,0.0002862438,0.00002700791,0.0004028851],"genre_scores_gemma":[0.9980401,0.00009596939,0.001233498,0.000006731827,0.000008813532,0.00001140288,0.000456843,0.000003308913,0.0001433189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002120307,"threshold_uncertainty_score":0.004192829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06722616256275228,"score_gpt":0.3548491110694873,"score_spread":0.287622948506735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}