{"id":"W2213019825","doi":"10.1016/s1474-4422(15)00012-5","title":"Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial","year":2015,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Health and Medical Research Council; Scottish Funding Council; Norges Forskningsråd; Dalhousie University; Schweizerische Herzstiftung; National Research Foundation; Karolinska Institutet; National Institute for Health and Care Research; University of Edinburgh; Chest Heart and Stroke Scotland; Stockholms Läns Landsting; National Institute for Social Care and Health Research","keywords":"Medicine; Randomized controlled trial; Stroke (engine); Odds ratio; Leukoaraiosis; Fibrinolytic agent; Internal medicine; Surgery; Cardiology; Pediatrics; Tissue plasminogen activator; Magnetic resonance imaging; Radiology; Hyperintensity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008587982,0.002508321,0.006125829,0.000631063,0.0005253266,0.001728233,0.001302789,0.002187131,0.004675656],"category_scores_gemma":[0.00831255,0.0005619011,0.007147836,0.001178234,0.00129779,0.001264262,0.0006749787,0.002614223,0.0005229934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001035389,"about_ca_system_score_gemma":0.001435151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001021152,"about_ca_topic_score_gemma":0.001477509,"domain_scores_codex":[0.9949469,0.003357891,0.0005003274,0.0005275142,0.0002960284,0.0003713946],"domain_scores_gemma":[0.9923636,0.002878455,0.002482279,0.0008157044,0.000615465,0.0008444626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9896011,0.0007772209,0.001889792,0.0007520034,0.004150475,0.00003200033,0.00002482499,0.0002117977,0.0004211609,0.00006105866,0.0002818207,0.001796641],"study_design_scores_gemma":[0.9231126,0.04694875,0.01580711,0.0001559797,0.01115119,0.00007137778,0.00003405528,0.0012046,0.0004671998,0.0004654873,0.00053379,0.00004799276],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848543,0.006389656,0.000794179,0.0003760636,0.0004417988,0.003489702,0.002157878,0.00008719053,0.001409288],"genre_scores_gemma":[0.9862612,0.001573912,0.001121745,0.0004100761,0.0006171322,0.006634003,0.002316709,0.00002764148,0.001037621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008587982,"threshold_uncertainty_score":0.04541814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01624108133024547,"score_gpt":0.2866598264065996,"score_spread":0.2704187450763542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}