{"id":"W2213019825","doi":"10.1016/s1474-4422(15)00012-5","title":"Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial","year":2015,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":204,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; National Health and Medical Research Council; Scottish Funding Council; Norges Forskningsråd; Dalhousie University; Schweizerische Herzstiftung; National Research Foundation; Karolinska Institutet; National Institute for Health and Care Research; University of Edinburgh; Chest Heart and Stroke Scotland; Stockholms Läns Landsting; National Institute for Social Care and Health Research","keywords":"Medicine; Randomized controlled trial; Stroke (engine); Odds ratio; Leukoaraiosis; Fibrinolytic agent; Internal medicine; Surgery; Cardiology; Pediatrics; Tissue plasminogen activator; Magnetic resonance imaging; Radiology; Hyperintensity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005044652,0.0001922999,0.00125317,0.000401849,0.0000339757,0.00003955708,0.000266375,0.00009915583,0.00002012166],"category_scores_gemma":[0.002119178,0.0001184888,0.0001665853,0.0002102768,0.00008798103,0.00006538119,0.0001669297,0.0004865178,0.000002343904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006798358,"about_ca_system_score_gemma":0.0000800315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008940376,"about_ca_topic_score_gemma":0.00004840331,"domain_scores_codex":[0.9969984,0.00130911,0.0006176335,0.0003196583,0.0004217223,0.0003334865],"domain_scores_gemma":[0.9957193,0.003380655,0.000369248,0.0003650341,0.00007468021,0.00009111172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9146265,0.00006069217,0.07557812,0.000003663735,0.003314879,0.00009562936,0.001952665,0.00001134335,0.00169534,0.0000039786,0.002214457,0.000442737],"study_design_scores_gemma":[0.8224524,0.001700059,0.1700562,0.000004414982,0.003267679,0.000008578852,0.00007364355,0.000509774,0.00003140258,0.00002506263,0.00177352,0.00009731083],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9340064,0.0000613363,0.00008668938,0.06206381,0.0002617506,0.002852734,0.000196523,0.00001959273,0.000451177],"genre_scores_gemma":[0.9894788,0.00002285706,0.00005580185,0.009095073,0.0003719073,0.0002811969,0.00003086777,0.00001439086,0.0006491574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09447807,"threshold_uncertainty_score":0.4831834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01624108133024547,"score_gpt":0.2866598264065996,"score_spread":0.2704187450763542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}