{"id":"W2213285461","doi":"10.3747/co.22.2700","title":"Does CDKN2A Loss Predict Palbociclib Benefit?","year":2015,"lang":"en","type":"article","venue":"Current Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. Food and Drug Administration; Incyte; Pfizer","keywords":"Palbociclib; CDKN2A; Medicine; Letrozole; Kinase; Breast cancer; Estrogen receptor; Oncology; Cancer research; Internal medicine; Cyclin-dependent kinase; Regulator; Cancer; Pharmacology; Metastatic breast cancer; Cell cycle; Biology; Tamoxifen; Cell biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005486039,0.0002135584,0.0004659813,0.0004904122,0.0002362966,0.0005521249,0.0002711895,0.0007932365,0.001846697],"category_scores_gemma":[0.002106358,0.0001087753,0.000251974,0.0004346353,0.0004571113,0.0006516144,0.0001799839,0.0007383881,0.0005502871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003963161,"about_ca_system_score_gemma":0.0003056766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008561698,"about_ca_topic_score_gemma":0.001482449,"domain_scores_codex":[0.9997653,0.00005481553,0.00003679418,0.00004250967,0.00004737031,0.00005314961],"domain_scores_gemma":[0.9990383,0.0004140408,0.0002662151,0.00003454951,0.00009766169,0.000149305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00141694,0.00009031912,0.9704885,0.00004337214,0.00005404931,0.004971389,0.00005257687,0.0003328819,0.004644449,0.0002124064,0.001078818,0.0166143],"study_design_scores_gemma":[0.0001688239,0.001139577,0.9401757,0.00005926786,0.0001913929,0.0413816,0.0006816399,0.005638644,0.003444643,0.001507877,0.005585109,0.00002574197],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866005,0.00269412,0.000312927,0.002892178,0.00005665687,0.00003859763,0.0002808049,0.00001115627,0.007113084],"genre_scores_gemma":[0.9985263,0.0004682585,0.0001414009,0.0003541045,0.00007261578,0.000007054664,0.0001537429,0.000002935506,0.0002733668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001846697,"threshold_uncertainty_score":0.006177843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1058741046390362,"score_gpt":0.4210296053006268,"score_spread":0.3151555006615906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}