{"id":"W2213421170","doi":"10.1371/journal.pone.0145583","title":"Expression of CCAAT/Enhancer Binding Protein Beta in Muscle Satellite Cells Inhibits Myogenesis in Cancer Cachexia","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Weill Cornell Medical College; National Institutes of Health; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Myogenesis; Myogenin; Cachexia; Myocyte; MyoD; Skeletal muscle; Endocrinology; Muscle atrophy; Biology; Cancer research; Internal medicine; Ccaat-enhancer-binding proteins; Cancer cell; Cancer; Transcription factor; Medicine; Nuclear protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603869,0.0001239268,0.0002117687,0.00008095285,0.00001591635,0.000003548759,0.0001241759,0.0001758579,0.00002349064],"category_scores_gemma":[0.00003583893,0.0001229031,0.00003434088,0.0001554318,0.00005573824,0.000006908027,0.0000943963,0.0000890546,0.00000673081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002418154,"about_ca_system_score_gemma":0.00008882664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002228979,"about_ca_topic_score_gemma":0.0004275848,"domain_scores_codex":[0.9990261,0.00008726873,0.0002353492,0.0002967967,0.0001271896,0.0002272895],"domain_scores_gemma":[0.9995627,0.000007131564,0.00009075039,0.0002201144,0.00005481466,0.00006446859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001807646,0.0006565165,0.006812432,0.00009631952,0.00001751601,9.446316e-7,0.0001690592,0.00006877071,0.991317,0.000003081033,0.00002941602,0.0006481335],"study_design_scores_gemma":[0.000792074,0.000111444,0.003692279,0.0002524398,0.00000966814,4.365861e-8,0.0001006756,0.00001555965,0.9947746,0.00003935549,0.00006807168,0.0001438216],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971318,0.002019144,0.000003966573,0.00005803709,0.0000247209,0.0003039326,0.00001532048,0.000005565371,0.0004374681],"genre_scores_gemma":[0.9987148,0.0004684137,0.000314535,0.00002113643,0.00004614671,0.0001226224,0.00003956987,0.00001720333,0.0002555678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003457521,"threshold_uncertainty_score":0.5011844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04576290866571308,"score_gpt":0.2570015697053941,"score_spread":0.211238661039681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}