{"id":"W2213525431","doi":"10.1038/mp.2015.158","title":"Optimal duration of risperidone or olanzapine adjunctive therapy to mood stabilizer following remission of a manic episode: A CANMAT randomized double-blind trial","year":2015,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut Universitaire en Santé Mentale de Québec; Queen's University; Douglas Mental Health University Institute; St. Paul's Hospital; University of Alberta; Université de Montréal; Sunnybrook Health Science Centre; Centre for Advancing Health Outcomes; University of Toronto; Western University; University Health Network; McGill University; University of British Columbia","funders":"Cilag; Janssen Canada; Pfizer Canada; St. Jude Medical; H. Lundbeck A/S; Servier; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; National Alliance for Research on Schizophrenia and Depression; Hospital de Clínicas de Porto Alegre; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Valeant Pharmaceuticals International; Fundação Instituto de Pesquisas Econômicas; Canadian Institutes of Health Research; Sunovion; Instituto Nacional de Ciência e Tecnologia Translacional em Medicina; Pfizer","keywords":"Olanzapine; Risperidone; Mood stabilizer; Mania; Discontinuation; Atypical antipsychotic; Internal medicine; Placebo; Randomized controlled trial; Hazard ratio; Adjunctive treatment; Antipsychotic; Medicine; Psychology; Bipolar disorder; Lithium (medication); Psychiatry; Confidence interval; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002184259,0.001189395,0.003551498,0.0005895885,0.0004753617,0.001408567,0.0009974721,0.002642765,0.008199387],"category_scores_gemma":[0.002937557,0.0007857704,0.001959351,0.0005328229,0.001188064,0.001241612,0.0005726301,0.002072463,0.001160451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001093555,"about_ca_system_score_gemma":0.001143533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009961606,"about_ca_topic_score_gemma":0.002476888,"domain_scores_codex":[0.9989676,0.0005635061,0.00008524355,0.0001770276,0.00007144018,0.0001351422],"domain_scores_gemma":[0.9983487,0.0004739687,0.0003887903,0.0001499882,0.00008891511,0.0005495847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9905189,0.00282887,0.0001507877,0.0003294658,0.0003926369,0.00001187319,0.00001649919,0.00009284603,0.0005756351,0.0000431154,0.0002843506,0.004755102],"study_design_scores_gemma":[0.97931,0.01940997,0.0005195506,0.00003015872,0.0002395113,0.00001044073,0.000008909666,0.0001674061,0.0001021219,0.00006300622,0.0001319108,0.000006926881],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982312,0.008234126,0.0005157215,0.00102432,0.001148238,0.002444243,0.000743362,0.0001839398,0.003394105],"genre_scores_gemma":[0.9858862,0.003002079,0.001348694,0.00142972,0.0008404434,0.003337195,0.0008010688,0.00002594665,0.003328548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008199387,"threshold_uncertainty_score":0.0274297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0365890751883903,"score_gpt":0.3291082838563251,"score_spread":0.2925192086679348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}