{"id":"W2213548494","doi":"10.1038/ng.3333","title":"Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations","year":2015,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":555,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Human Genome Research Institute; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Universiteit van Amsterdam; Fondation Nelia et Amadeo Barletta; Agence Nationale de la Recherche; National Institute on Minority Health and Health Disparities; Annenberg Foundation","keywords":"Biology; Neuroblastoma; MAPK/ERK pathway; Cancer research; Somatic cell; Phenotype; Mutation; In vivo; Germline mutation; Genotype; Genetics; Cell culture; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002458458,0.0004158149,0.0004037311,0.001016405,0.000352508,0.0006550064,0.0003714683,0.0006710546,0.004005128],"category_scores_gemma":[0.0007627996,0.0002130313,0.0003877701,0.0009849886,0.0003232848,0.0004226863,0.0004803091,0.0003541707,0.001546562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003243462,"about_ca_system_score_gemma":0.0002156638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001510455,"about_ca_topic_score_gemma":0.002130066,"domain_scores_codex":[0.9997107,0.00002498878,0.00003640752,0.00006027367,0.0001143167,0.0000533596],"domain_scores_gemma":[0.9995549,0.00008763284,0.0001345508,0.00007124296,0.00008823244,0.00006351739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001017015,0.00007349391,0.3112758,0.0002190736,0.0002072346,0.09648342,0.000631798,0.0006119019,0.5285891,0.001141821,0.002994678,0.05675463],"study_design_scores_gemma":[0.00004159268,0.0002557125,0.5385693,0.0000541495,0.0003009113,0.355637,0.001120762,0.0009926198,0.08670666,0.001594638,0.01468066,0.00004597664],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844723,0.002337236,0.001154448,0.0003064699,0.0000552694,0.00002110242,0.001104044,0.0002115311,0.01033761],"genre_scores_gemma":[0.9963636,0.0006097293,0.0008916463,0.00005564707,0.00002384051,0.000007086581,0.0005704126,0.0000374952,0.001440691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004005128,"threshold_uncertainty_score":0.01339853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02693391353906878,"score_gpt":0.3070803402388448,"score_spread":0.280146426699776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}