{"id":"W2213746779","doi":"10.1073/pnas.1517642113","title":"Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"National Cancer Institute; National Institutes of Health; Vetenskapsrådet; Hjärt-Lungfonden; British Heart Foundation; Wellcome Trust; Wellcome","keywords":"Cyclooxygenase; NFAT; Inflammation; Limiting; Pharmacology; Signal transduction; Medicine; Bioinformatics; Biology; Enzyme; Transcription factor; Immunology; Cell biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004863553,0.0002677556,0.0003277627,0.0004872065,0.0002324079,0.0003807893,0.0002163604,0.0002251526,0.0006014873],"category_scores_gemma":[0.0002390984,0.0001429586,0.0002828869,0.0005026205,0.0003801424,0.0004648733,0.0002921693,0.0005589169,0.0001739159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002579223,"about_ca_system_score_gemma":0.0004839346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000443667,"about_ca_topic_score_gemma":0.0008005572,"domain_scores_codex":[0.9997653,0.00004122435,0.00002747428,0.00006856713,0.0000520139,0.00004543951],"domain_scores_gemma":[0.9997033,0.00004927405,0.00006815114,0.00004703099,0.00008675116,0.00004542889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002486971,0.00004352472,0.002515507,0.0002906939,0.00001977614,0.0001062127,0.00004474962,0.00003119805,0.99075,0.0001930714,0.00003146602,0.005725119],"study_design_scores_gemma":[0.00004639737,0.0009032863,0.0908279,0.00008697285,0.0002418674,0.003066404,0.0003090372,0.0007342139,0.8901482,0.0005000061,0.01311419,0.00002160897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9284667,0.04794931,0.0191407,0.0001877127,0.0000724905,0.0001331728,0.0008391237,0.0000704619,0.003140378],"genre_scores_gemma":[0.9621142,0.02347428,0.01019592,0.0001794728,0.00007035312,0.0001236297,0.001246513,0.00002723131,0.002568417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006014873,"threshold_uncertainty_score":0.002572119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04886937309817989,"score_gpt":0.2927392322350888,"score_spread":0.2438698591369089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}