{"id":"W2214176334","doi":"10.1038/nm.3943","title":"The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development","year":2015,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":443,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; Wellcome Trust","keywords":"Biology; Histone methyltransferase; EZH2; Cancer research; Germinal center; Histone H3; SOCS3; Epigenetics; Histone methylation; Gene; Genetics; B cell; DNA methylation; Gene expression; Suppressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005202107,0.0002339497,0.0002053776,0.00006164785,0.0001755718,0.00001711577,0.000253712,0.0004334349,0.00001014543],"category_scores_gemma":[0.0002279373,0.0001476063,0.00005549383,0.0002108092,0.0001728408,0.000005739229,0.00008009082,0.0002074392,0.000003340641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001513561,"about_ca_system_score_gemma":0.000355442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002462968,"about_ca_topic_score_gemma":0.00005835743,"domain_scores_codex":[0.9983773,0.00009590242,0.0002769038,0.0004448875,0.0004918104,0.0003132541],"domain_scores_gemma":[0.9987738,0.00003021314,0.0001206022,0.0005666119,0.0003178506,0.0001909697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005407339,0.0001830762,0.0001928356,0.00003897095,0.00006876817,0.00001558702,0.0004651379,0.00009912976,0.8874488,0.00001401048,0.03166394,0.07926897],"study_design_scores_gemma":[0.001666475,0.0002003091,0.0004848515,0.00003148808,0.00003444617,0.00001890519,0.0001472535,0.0000213312,0.6328691,0.00002287451,0.3643784,0.0001245639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8931417,0.09650723,0.002936893,0.003664149,0.001146289,0.0009386556,0.000005488756,0.00009183853,0.001567725],"genre_scores_gemma":[0.9919399,0.0008550099,0.002758592,0.0002409837,0.0007996493,0.0001051009,0.0004182905,0.00003791981,0.002844563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3327144,"threshold_uncertainty_score":0.601921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191136839147539,"score_gpt":0.2988795680642486,"score_spread":0.2869681996727733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}