{"id":"W2214455720","doi":"10.1158/1078-0432.ccr-14-3215","title":"Next-Generation Sequencing to Guide Clinical Trials","year":2015,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute","keywords":"Clinical trial; Medicine; Computational biology; Intensive care medicine; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02495691,0.001368771,0.002842729,0.002833735,0.0003341543,0.003323418,0.002465063,0.003630416,0.01042373],"category_scores_gemma":[0.03855505,0.0005895076,0.001594571,0.001910184,0.001619976,0.003054914,0.001709935,0.006368164,0.005408187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001734337,"about_ca_system_score_gemma":0.006620374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001317161,"about_ca_topic_score_gemma":0.001808107,"domain_scores_codex":[0.9926616,0.00445875,0.0007287675,0.00050438,0.001471918,0.0001745052],"domain_scores_gemma":[0.9682796,0.02562829,0.001463146,0.0009084634,0.003051671,0.0006687917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002156621,0.0001059582,0.0003768198,0.009851652,0.0003671238,0.0001524253,0.00009766055,0.001371176,0.0007292852,0.02050886,0.06710678,0.8991166],"study_design_scores_gemma":[0.000307188,0.0002242544,0.0008128095,0.01566665,0.0003662739,0.0005517733,0.00008970169,0.0009658669,0.0008227908,0.05483383,0.9252939,0.0000649729],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004634943,0.9287896,0.02728211,0.02196396,0.005073069,0.0007410762,0.0006015884,0.0003197197,0.01476547],"genre_scores_gemma":[0.007113441,0.8932536,0.06588946,0.0210694,0.004278934,0.00190067,0.0009937085,0.0001248183,0.005376081],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02495691,"threshold_uncertainty_score":0.1319863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.87215389658377,"score_gpt":0.6872007949276112,"score_spread":0.1849531016561587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}