{"id":"W2214455720","doi":"10.1158/1078-0432.ccr-14-3215","title":"Next-Generation Sequencing to Guide Clinical Trials","year":2015,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute","keywords":"Clinical trial; Medicine; Computational biology; Intensive care medicine; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.05495032,0.0004349378,0.002999456,0.0001956583,0.0001595225,0.0002468209,0.0010729,0.001435273,0.0001336916],"category_scores_gemma":[0.04512158,0.0003588375,0.001422582,0.0004753296,0.000316825,0.000005260118,0.001055163,0.001506334,0.0003884723],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005855517,"about_ca_system_score_gemma":0.01253727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003640383,"about_ca_topic_score_gemma":0.0006874058,"domain_scores_codex":[0.9861723,0.006602239,0.004074072,0.001597138,0.0007611366,0.0007930901],"domain_scores_gemma":[0.9927615,0.002806267,0.0006259915,0.001473559,0.001261968,0.001070739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005661548,0.00004793929,0.00001692952,0.000378554,0.0001652041,0.000009018962,0.000004489051,0.000008541008,0.00005422832,0.00002601387,0.327867,0.6713654],"study_design_scores_gemma":[0.0005187016,0.0008717757,0.00000200916,0.001099442,0.0002672325,0.000005093223,0.00001600427,0.00002163308,0.00003483398,0.00004162545,0.9967108,0.000410874],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002718256,0.9923993,0.000194769,0.0002999161,0.003130988,0.002042071,0.0003840128,0.00001442431,0.001262727],"genre_scores_gemma":[0.00002372722,0.9713593,0.0006019869,0.0007194969,0.02258555,0.0007555827,0.0006427151,0.0001215014,0.003190203],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6709545,"threshold_uncertainty_score":0.9998863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.87215389658377,"score_gpt":0.6872007949276112,"score_spread":0.1849531016561587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}