{"id":"W2214906022","doi":"10.1371/journal.pone.0144555","title":"Modulation of Malaria Phenotypes by Pyruvate Kinase (PKLR) Variants in a Thai Population","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Agence Nationale de la Recherche","keywords":"Plasmodium chabaudi; Biology; Malaria; Plasmodium falciparum; Parasitemia; Population; Pyruvate kinase deficiency; Pyruvate kinase; Haplotype; Plasmodium vivax; Genetics; Allele; Gene; Virology; Immunology; Glycolysis; Medicine; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002848534,0.0002485823,0.000178567,0.0004768349,0.0006139796,0.000522249,0.0001274302,0.0001522474,0.001241483],"category_scores_gemma":[0.0008971659,0.0001809132,0.0002000703,0.0008812635,0.0003333906,0.0002208317,0.0004084944,0.0003426313,0.0001551114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001893928,"about_ca_system_score_gemma":0.0002064199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005278526,"about_ca_topic_score_gemma":0.003623472,"domain_scores_codex":[0.9996512,0.0001164714,0.00003220369,0.00009906058,0.00004934174,0.00005170323],"domain_scores_gemma":[0.9994962,0.00008271191,0.0001916531,0.00004125258,0.0000575593,0.0001305878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002382504,0.0003808867,0.9046159,0.00007174953,0.0002116724,0.003676048,0.006176593,0.0003971501,0.0626303,0.0002608036,0.000358773,0.01883763],"study_design_scores_gemma":[0.00004520009,0.001207223,0.9857436,0.00001752985,0.0000976512,0.005167771,0.003285915,0.0009459928,0.002384118,0.0002115927,0.0008556193,0.00003788972],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996493,0.00002199368,0.0001030321,0.000009640813,8.855175e-7,0.000003899582,0.00007957753,0.000001690184,0.0001301461],"genre_scores_gemma":[0.9994701,0.00005063941,0.0001238335,0.00001126192,0.000002732306,0.000006110753,0.0001541853,0.000002565621,0.0001787398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005278526,"threshold_uncertainty_score":0.0104956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04582863433725459,"score_gpt":0.2516384190389847,"score_spread":0.2058097847017301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}