{"id":"W2215476320","doi":"10.1182/blood.v122.21.437.437","title":"Fine-Mapping and Genome Editing Reveal An Essential Erythroid Enhancer At The HbF-Associated BCL11A Locus","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Biology; Chromosome conformation capture; Enhancer; Genetics; Locus (genetics); Chromatin; Transcription activator-like effector nuclease; Genome editing; Chromatin immunoprecipitation; CRISPR; Transcription factor; Gene; Molecular biology; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001882262,0.0002645628,0.0002080604,0.000354609,0.0001782166,0.0002490831,0.0002609093,0.0003059673,0.002773236],"category_scores_gemma":[0.0002264126,0.0001207346,0.0003435262,0.0002066949,0.0002485913,0.00005596679,0.000257127,0.0004210664,0.0004173219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002068455,"about_ca_system_score_gemma":0.0001356088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000961124,"about_ca_topic_score_gemma":0.002553978,"domain_scores_codex":[0.9997957,0.00003271973,0.00001890299,0.00007878673,0.00004573758,0.00002803545],"domain_scores_gemma":[0.9997512,0.00008385645,0.00007009931,0.00003450137,0.00001528659,0.00004517715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009524542,0.00002448847,0.002253224,0.0000277101,0.00002468136,0.0002450652,0.00002393692,0.000198086,0.9940276,0.0001495443,0.00006621474,0.002864225],"study_design_scores_gemma":[0.00009851576,0.0003813668,0.1722964,0.00003287147,0.0001840508,0.005208977,0.000106074,0.00517671,0.8070162,0.0004305095,0.009036049,0.00003237577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855699,0.0002654739,0.01174898,0.00008265041,0.00002215586,0.00003841567,0.001218324,0.0001734901,0.0008806158],"genre_scores_gemma":[0.9939984,0.00009768301,0.004060389,0.00006197527,0.00000630931,0.0000185048,0.0006428298,0.00004362363,0.001070184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002773236,"threshold_uncertainty_score":0.009277344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006346121305916081,"score_gpt":0.2168886662852952,"score_spread":0.2105425449793792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}