{"id":"W2215537962","doi":"10.1007/978-94-010-0765-8_1","title":"Calcineurin-Targeted Inhibition of Immune Reactivity","year":2001,"lang":"en","type":"book-chapter","venue":"","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Calcineurin; Tacrolimus; FKBP; Immune system; Sirolimus; Drug; Pharmacology; Drug discovery; Biology; Chemistry; Transplantation; Cell biology; Immunology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001039155,0.000252758,0.0002636242,0.00004992587,0.00002432131,0.000005092075,0.0001150053,0.0004246916,0.0005176801],"category_scores_gemma":[0.00005661625,0.0002552513,0.0002580362,0.00001664805,0.00009819838,0.000001419469,0.0001220981,0.0001475203,0.00002862177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001704591,"about_ca_system_score_gemma":0.00008862776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002474305,"about_ca_topic_score_gemma":0.000008444495,"domain_scores_codex":[0.9989626,0.00001643746,0.0003287969,0.0003780403,0.0001676751,0.0001464053],"domain_scores_gemma":[0.9989687,0.00001090259,0.0002415871,0.000576724,0.0001301744,0.00007190216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001186663,0.00005378735,0.0000315233,0.0000477863,0.00008098522,0.00002379911,0.000003421953,0.000007141259,0.9931035,0.002298366,0.00319811,0.001032937],"study_design_scores_gemma":[0.0003360639,0.0001618293,0.00007746659,0.00007172421,0.00005830099,0.00001375526,0.000001783389,0.000002152431,0.9109074,0.001242292,0.08684577,0.0002814021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.1202167,0.001746045,0.0005004496,0.00005173523,0.0002227783,0.0003101982,0.0001911139,0.00004096594,0.8767201],"genre_scores_gemma":[0.6748763,0.0002226261,0.00013449,0.00009519427,0.000285237,0.000007355658,0.001017107,0.00007158914,0.3232901],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.5546596,"threshold_uncertainty_score":0.99999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479774061236306,"score_gpt":0.2353886699420377,"score_spread":0.2205909293296747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}