{"id":"W2215537962","doi":"10.1007/978-94-010-0765-8_1","title":"Calcineurin-Targeted Inhibition of Immune Reactivity","year":2001,"lang":"en","type":"book-chapter","venue":"","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Calcineurin; Tacrolimus; FKBP; Immune system; Sirolimus; Drug; Pharmacology; Drug discovery; Biology; Chemistry; Transplantation; Cell biology; Immunology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000118362,0.0005200766,0.0003349546,0.000355382,0.0002019062,0.0005320815,0.0005561594,0.0004341288,0.002559626],"category_scores_gemma":[0.00007761401,0.0001759585,0.0002511212,0.0002959791,0.0002580807,0.0003307078,0.0002334172,0.001189378,0.001039928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005294136,"about_ca_system_score_gemma":0.0002266694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004198503,"about_ca_topic_score_gemma":0.001208732,"domain_scores_codex":[0.9999285,0.00000740725,0.000002758164,0.00001320723,0.00003347807,0.00001471559],"domain_scores_gemma":[0.9999839,0.000006416001,0.000002058185,0.000002416823,0.000002027039,0.000003160002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002899948,0.0002467282,0.00006815072,0.0004685177,0.00003608442,0.0004682332,0.00008572343,0.001524773,0.7603503,0.03124679,0.01407301,0.1911416],"study_design_scores_gemma":[0.00008699021,0.0004372911,0.001089033,0.00008516559,0.0000554275,0.00154644,0.00003183352,0.001938235,0.6787353,0.007920668,0.3080436,0.00002999989],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.1723878,0.4338726,0.05502032,0.004566631,0.003825153,0.0002471767,0.001003071,0.002231645,0.3268456],"genre_scores_gemma":[0.5763776,0.1727273,0.01659308,0.001805441,0.0005008788,0.00029016,0.000700655,0.0002163898,0.2307885],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002559626,"threshold_uncertainty_score":0.008562803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479774061236306,"score_gpt":0.2353886699420377,"score_spread":0.2205909293296747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}